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    Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain

    Autor: 
    Requena, S.
    ;
    Caballero, Estrella
    ;
    Lozano, A. B.
    ;
    Ríos-Villegas, María
    ;
    Benito, Rafael
    ;
    Rojo, Silvia
    ;
    Cabezas, Teresa
    ;
    Macià, María
    ;
    Nieto, María del
    ;
    Soriano, Vicente
    ;
    Mendoza, Carmen de
    Fecha: 
    15/11/2019
    Palabra clave: 
    antiretrovirals; HIV-1; HIV-2; Scopus; JCR
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/9879
    DOI: 
    https://doi.org/10.1097/QAD.0000000000002338
    Dirección web: 
    https://insights.ovid.com/crossref?an=00002030-201911150-00006
    Resumen:
    Background: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all dually infected patients living in Spain.Methods:We identified retrospectively all persons coinfected with HIV-1 recorded at the Spanish HIV-2 registry. Dual infection had been confirmed using PCR in plasma and/or cells, and/or using discriminatory serological tests.Results:From a total of 373 individuals with HIV-2 recorded at the Spanish registry, 34 (9.1%) were coinfected with HIV-1. Compared with HIV-2 monoinfected persons, dually infected patients were more often male (67.6%), presented with lower median CD4+ cell counts (204 cells/μl), and had developed more frequently AIDS events (26.5%). Although 61.7% came from West Africa, 6 (17.6%) were native Spaniards. HIV-1 non-B subtypes were recognized in 75% of coinfected patients, being the most prevalent CRF02-AG. At baseline, 45% of dually infected patients had undetectable plasma HIV-2 RNA. After a median follow-up of 32 (13-48) months on antiretroviral therapy, dually infected patients achieved undetectable viremia in 85% for HIV-1, in 80% for HIV-2; and in 70% for both viruses. Median CD4+ cell counts reached up to 418 cells/μl.Conclusion:Roughly 9% of individuals with HIV-2 infection living in Spain are coinfected with HIV-1. Overall, 70% of dually infected patients achieved viral suppression for both viruses under antiretroviral therapy. Given the relatively large population of West Africans living in Spain and the continuous migration flow from HIV-2 endemic areas, HIV-1/HIV-2 coinfection should always be excluded at first diagnosis in all HIV-seroreactive persons.
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