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dc.contributor.authorRequena, S.
dc.contributor.authorCaballero, Estrella
dc.contributor.authorLozano, A. B.
dc.contributor.authorRíos-Villegas, María
dc.contributor.authorBenito, Rafael
dc.contributor.authorRojo, Silvia
dc.contributor.authorCabezas, Teresa
dc.contributor.authorMacià, María
dc.contributor.authorNieto, María del
dc.contributor.authorSoriano, Vicente (1)
dc.contributor.authorMendoza, Carmen de
dc.date2019-11-15
dc.date.accessioned2020-03-06T09:51:57Z
dc.date.available2020-03-06T09:51:57Z
dc.identifier.issn02699370
dc.identifier.urihttps://reunir.unir.net/handle/123456789/9879
dc.description.abstractBackground: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all dually infected patients living in Spain.Methods:We identified retrospectively all persons coinfected with HIV-1 recorded at the Spanish HIV-2 registry. Dual infection had been confirmed using PCR in plasma and/or cells, and/or using discriminatory serological tests.Results:From a total of 373 individuals with HIV-2 recorded at the Spanish registry, 34 (9.1%) were coinfected with HIV-1. Compared with HIV-2 monoinfected persons, dually infected patients were more often male (67.6%), presented with lower median CD4+ cell counts (204 cells/μl), and had developed more frequently AIDS events (26.5%). Although 61.7% came from West Africa, 6 (17.6%) were native Spaniards. HIV-1 non-B subtypes were recognized in 75% of coinfected patients, being the most prevalent CRF02-AG. At baseline, 45% of dually infected patients had undetectable plasma HIV-2 RNA. After a median follow-up of 32 (13-48) months on antiretroviral therapy, dually infected patients achieved undetectable viremia in 85% for HIV-1, in 80% for HIV-2; and in 70% for both viruses. Median CD4+ cell counts reached up to 418 cells/μl.Conclusion:Roughly 9% of individuals with HIV-2 infection living in Spain are coinfected with HIV-1. Overall, 70% of dually infected patients achieved viral suppression for both viruses under antiretroviral therapy. Given the relatively large population of West Africans living in Spain and the continuous migration flow from HIV-2 endemic areas, HIV-1/HIV-2 coinfection should always be excluded at first diagnosis in all HIV-seroreactive persons.es_ES
dc.language.isoenges_ES
dc.publisherAIDSes_ES
dc.relation.ispartofseries;vol. 33, nº 14
dc.relation.urihttps://insights.ovid.com/crossref?an=00002030-201911150-00006es_ES
dc.rightsrestrictedAccesses_ES
dc.subjectantiretroviralses_ES
dc.subjectHIV-1es_ES
dc.subjectHIV-2es_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleTreatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spaines_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1097/QAD.0000000000002338


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