HIV co-infection in HTLV-1 carriers in Spain
Mendoza, Carmen de
Soriano, Vicente (1)
Corral, Octavio Jorge (1)
Gómez-Gallego, Felix (1)
Tipo de Ítem:Articulo Revista Indexada
Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain. Methods: A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection. Results: Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia). HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection. Conclusion: HIV coinfection is infrequent (< 5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.
Este ítem aparece en la(s) siguiente(s) colección(es)
Mostrando ítems relacionados por Título, autor o materia.
Mendoza, Carmen de; Pirón, María; González, Rocío; Jiménez, Ana; Caballero, Estrella; Roc, Lourdes; Benito, Rafael; Soriano, Vicente (1); Corral, Octavio Jorge (1); ...et al.; Gómez-Gallego, Felix (1) (Open Forum Infectious Diseases, 02/2019)Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late ...
Mendoza, Carmen de; Roc, Lourdes; Benito, Rafael; Reina, Gabriel; Ramos, José M.; Gómez, Cesar; Soriano, Vicente (1); Corral, Octavio Jorge (1); ...et al.; Gómez-Gallego, Felix (1) (BMC Invectious Diseases, 09/08/2019)Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ...
Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals Roc, Lourdes; Mendoza, Carmen de; Fernández-Alonso, Miriam; Reina, Gabriel; Soriano, Vicente (1); Rodriguez, C.; ...et al.; Corral, Octavio Jorge (1); Gómez-Gallego, Felix (1) (Therapeutic Advances in Infectious Disease, 08/2019)Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral ...