Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
Mendoza, Carmen de;
Soriano, Vicente (1);
Corral, Octavio Jorge (1);
Gómez-Gallego, Felix (1)
Tipo de Ítem:Articulo Revista Indexada
Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late diagnoses. Methods. A nationwide HTLV-1 register was created in Spain in 1989. A total of 351 infected persons had been reported by the end of 2017. We examined all new HTLV-1 diagnoses during the last decade and compared their clinical presentation. Results. A total of 247 individuals with HTLV-1 infection had been reported in Spain since year 2008. The incidence has remained stable with 20-25 new diagnoses yearly. Women represented 62%. Only 12% were native Spaniards, most of whom were foreigners from Latin America (72.5%). Up to 57 (23%) individuals presented clinically with HTLV-1-associated conditions, including subacute myelopathy (n = 24; 42.1%), T-cell lymphoma (n = 19; 33.3%), or Strongyloides stercoralis infestation (n = 8; 14%). Human T-cell leukemia virus type 1 diagnosis had been made either at blood banks (n = 109; 44%) or at clinics (n = 138; 56%). It is interesting to note that Spaniards and especially Africans were overrepresented among patients presenting with HTLV-1-associated illnesses, suggesting that misdiagnosis and late presentation are more frequent in these populations compared to Latin Americans. Conclusions. Given that 23% of new HTLV-1 diagnoses in Spain are symptomatic, underdiagnosis must be common. Although screening in blood banks mostly identifies asymptomatic Latin American carriers, a disproportionately high number of Spaniards and Africans are unveiled too late, that is, they already suffer from classic HTLV-1 illnesses.
Este ítem aparece en la(s) siguiente(s) colección(es)
Estadísticas de uso
Mostrando ítems relacionados por Título, autor o materia.
Mendoza, Carmen de; Caballero, Estrella; Aguilera, Antonio; Benito, Rafael; Maciá, Dolores; García-Costa, Juan; Soriano, Vicente (1); Corral, Octavio Jorge (1); Gómez-Gallego, Felix (1); ...et al.; Morano, Luis (Virus Research, 06/2019)Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. ...
Mendoza, Carmen de; Roc, Lourdes; Benito, Rafael; Reina, Gabriel; Ramos, José M.; Gómez, Cesar; Soriano, Vicente (1); Corral, Octavio Jorge (1); ...et al.; Gómez-Gallego, Felix (1) (BMC Invectious Diseases, 09/08/2019)Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ...
Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals Roc, Lourdes; Mendoza, Carmen de; Fernández-Alonso, Miriam; Reina, Gabriel; Soriano, Vicente (1); Rodriguez, C.; ...et al.; Corral, Octavio Jorge (1); Gómez-Gallego, Felix (1) (Therapeutic Advances in Infectious Disease, 08/2019)Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral ...