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dc.contributor.authorMendoza, Carmen de
dc.contributor.authorCaballero, Estrella
dc.contributor.authorAguilera, Antonio
dc.contributor.authorBenito, Rafael
dc.contributor.authorMaciá, Dolores
dc.contributor.authorGarcía-Costa, Juan
dc.contributor.authorSoriano, Vicente (1)
dc.contributor.authorCorral, Octavio Jorge (1)
dc.contributor.authorGómez-Gallego, Felix (1) al.
dc.contributor.authorMorano, Luis
dc.description.abstractBackground: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. In contrast, HTLV-1 is not endemic in Spain, despite hosting huge numbers of migrants from highly endemic regions. Herein, we report the rate and main features of the HIV-HTLV co-infected population in Spain. Methods: A national registry exists in Spain for HTLV since year 1989. Data from standardized case report forms and one centralized lab repository were reviewed, especially for the subset with HTLV-HIV co-infection. Results: Up to December 2018, a total of 369 individuals with HTLV-1 had been diagnosed in Spain. 64% of the population were females, and Latin American individuals accounted for 64.5%. Classical HTLV-associated illnesses were found in 12.7% (myelopathy) and 7.6% (leukemia). HIV coinfection was found in 12 (3.2%). Of those, 3 patients (25%) were female and 39 (75%) were of non Spanish origin. All but two harbored HIV-1 subtype B, being non-B variants found in the two West Africans. Exposure had been sexual in most cases, being 4 homosexual men. Seven HTLV-HIV co-infected patients had developed AIDS and two had developed myelopathy. There was no evidence for increased HTLV-1 clinical pathogenicity due to HIV coinfection. Conclusion: HIV coinfection is infrequent (< 5%) among HTLV-1 carriers in Spain. More than half of co-infected patients come from Latin America. Sexual contact is the most frequent risk behavior, being MSM one third of cases. Late diagnosis explains the high rate (9/12) of clinical manifestations in our HIV-HTLV co-infected population.es_ES
dc.publisherVirus Researches_ES
dc.relation.ispartofseries;vol. 266
dc.subjecttropical spastic paraparesises_ES
dc.subjectadult T-cell leukemiaes_ES
dc.subjectantiretroviral therapyes_ES
dc.subjectlate diagnosises_ES
dc.titleHIV co-infection in HTLV-1 carriers in Spaines_ES
dc.typeArticulo Revista Indexadaes_ES

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