Prevalence and incidence of hepatitis delta in patients with chronic hepatitis B in Spain
Mendoza, Carmen de
Soriano, Vicente (1)
Tipo de Ítem:Articulo Revista Indexada
Background Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual HDV and hepatitis B virus exposure. Herein, we examined the global and incident rates of HDV infections in Spain. Patients and methods The presence of anti-HDV antibody and new HDV superinfections was examined in all HBsAg+ patients who attended one large tertiary outclinic in Spain since year 2000. Anti-HDV antibodies were tested repeatedly every 5 years in those previously negative. Results During a median follow-up of 12 years, 478 individuals were diagnosed as HBsAg+. Overall, 64.4% were male, median age was 55 years, 88.1% were native Spaniards, 6.5% were coinfected with HIV, and 7.3% were reactive for hepatitis C virus (HCV) antibodies. A total of 19 (4%) patients had anti-HDV antibody at first diagnosis. There were no further HDV seroconversions. Most anti-HDV + patients were male (n = 12), former injection drug users (n= 13), and native Spaniards (n= 16). Coinfection with HIV was found in six, and 12 had HCV antibodies. Interestingly, three of seven women with delta hepatitis were foreigners (Asian or African), denied injection drug use, were younger than 40 years old, and negative for both HCV and HIV. Conclusion The prevalence of chronic hepatitis delta is currently very low (< 5%) among chronic HBsAg+ carriers in Spain, with lower rates in recent years. Moreover, new incident HDV infections were not seen in 478 chronic hepatitis B carriers since year 2000, following drastic declines in injection drug use.
Este ítem aparece en la(s) siguiente(s) colección(es)
Mostrando ítems relacionados por Título, autor o materia.
Aguilera, Antonio; Rodríguez-Calviño, Javier; Mendoza, Carmen de; Soriano, Vicente (1) (European Journal of Gastroenterology & Hepatology, 09/2018)Background The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals ...
Aguilera, Antonio; Soriano, Vicente (1) (AIDS Reviews, 10/2018)In HIV disease, infection is universally followed by chronification, and therefore, recognition of anti-HIV antibodies always reflects HIV persistence.
Assessment of the Tourism’s Potential as a Sustainable Development Instrument in Terms of Annual Stability: Application to Spanish Rural Destinations in Process of Consolidation Martín Martín, José María (1); Salinas Fernández, José Antonio; Rodríguez Martín, José Antonio; Jiménez Aguilera, Juan de Dios (Sustainability, 2017)Tourism has established itself as an instrument that supports the sustainable development of rural destinations and has both, negative and positive effects. The annual instability of the flow of visitors, known as tourist ...