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    Hepatitis delta in patients with resolved hepatitis B virus infection

    Autor: 
    Aguilera, Antonio
    ;
    Rodríguez-Calviño, Javier
    ;
    Mendoza, Carmen de
    ;
    Soriano, Vicente
    Fecha: 
    09/2018
    Palabra clave: 
    hepatitis B; hepatitis C; hepatitis delta; HIV; occult hepatitis; JCR; Scopus
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/7677
    DOI: 
    https://doi.org/10.1097/MEG.0000000000001187
    Resumen:
    Background The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections? Methods We tested for HDV-antibodies 406 individuals with markers of past HBV exposure. Results Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes. Conclusion These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.
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