Hepatitis delta in patients with resolved hepatitis B virus infection
Mendoza, Carmen de
Soriano, Vicente (1)
Tipo de Ítem:Articulo Revista Indexada
Background The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections? Methods We tested for HDV-antibodies 406 individuals with markers of past HBV exposure. Results Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes. Conclusion These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.
Este ítem aparece en la(s) siguiente(s) colección(es)
Mostrando ítems relacionados por Título, autor o materia.
Aguilera, Antonio; Trastoy, Rocío; Rodríguez-Calviño, Javier; Manso, Tamara; Mendoza, Carmen de; Soriano, Vicente (1) (European Journal of Gastroenterology & Hepatology, 09/2018)Background Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual ...
Aguilera, Antonio; Soriano, Vicente (1) (AIDS Reviews, 10/2018)In HIV disease, infection is universally followed by chronification, and therefore, recognition of anti-HIV antibodies always reflects HIV persistence.
Assessment of the Tourism’s Potential as a Sustainable Development Instrument in Terms of Annual Stability: Application to Spanish Rural Destinations in Process of Consolidation Martín Martín, José María (1); Salinas Fernández, José Antonio; Rodríguez Martín, José Antonio; Jiménez Aguilera, Juan de Dios (Sustainability, 2017)Tourism has established itself as an instrument that supports the sustainable development of rural destinations and has both, negative and positive effects. The annual instability of the flow of visitors, known as tourist ...