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HTLV-1 infection and health outcomes
(The Lancet Infectious Diseases, 2020-04)
The meta-analysis published by Gill Schierhout and colleagues1 reported an increased relative risk of premature death in individuals infected with HTLV-1 compared with individuals not infected with HTLV-1 (RR 1·57, 95% CI ...
Why such excess of mortality for COVID-19 in Spain?
(Therapeutic Advances in Infectious Disease, 2020-06)
The current global crisis produced by the SARS-CoV-2 pandemic is unprecedented. Even the 1918 influenza pandemic (Spanish flu) did not halt the planet so abruptly and deeply as it ran during World War I.
Rapid antigen Testing and Mask Wearing While Waiting for COVID-19 Vaccines
(AIDS reviews, 2020)
After the rapid surge of COVID-19 in Europe during the spring of 2020, implementation of lockdowns succeeded in drastically reduce the number of cases and deaths within 2-3 months. However, it came at a heavy socioeconomic ...
Tough requirements for new antiretroviral drugs
(The Lancet HIV, 2020-03)
Medical and social attention to HIV infection has declined globally and is increasingly focused on developing regions, where the epidemic is still largely uncontrolled. In North America and western Europe, AIDS is rarely ...
Keeping alive enterprises while embracing unprecedented COVID-19 restrictions
(Therapeutic Advances in Infectious Disease, 2020-04)
COVID-19 is rapidly expanding globally, with more than 1,800,000 cases and 105,000 deaths to date (April 11, 2020) (www.worldometers.info). The WHO upgrade to pandemic, the emergency declaration in the United States, and ...
Advances in hepatitis B therapeutics
(Therapeutic Advances in Infectious Disease, 2020-10)
Despite the availability of both effective preventive vaccines and oral antivirals, over 250 million people are chronically infected with the hepatitis B virus (HBV). Globally, chronic hepatitis B is the leading cause of ...
Overt and occult hepatitis B among immigrants and native blood donors in Madrid, Spain
(Therapeutic Advances in Infectious Disease, 2020-12)
Background:
The risk of transfusion-transmitted viral infections is very low in developed countries. Recent massive migration flows from highly hepatitis B virus (HBV), hepatitis C virus (HCV) and/or HIV endemic regions ...
Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
(International Journal of Infectious Diseases, 2020-08)
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum ...
Screening for retroviruses and hepatitis viruses using dried blood spots reveals a high prevalence of occult hepatitis B in Ghana
(Therapeutic Advances in Infectious Disease, 2019-05)
Background: Recent advances in antiviral therapy show potential for a cure and/or control of most human infections caused by hepatitis viruses and retroviruses. However, medical success is largely dependent on the ...
Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
(Therapeutic Advances in Infectious Disease, 2019-08)
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral ...