Screening for retroviruses and hepatitis viruses using dried blood spots reveals a high prevalence of occult hepatitis B in Ghana
Mendoza, Carmen de
Bautista Vallejo, José Manuel
Soriano, Vicente (1)
Tipo de Ítem:Articulo Revista Indexada
Background: Recent advances in antiviral therapy show potential for a cure and/or control of most human infections caused by hepatitis viruses and retroviruses. However, medical success is largely dependent on the identification of the large number of people unaware of these infections, especially in developing countries. Dried blood spots (DBS) have been demonstrated to be a good tool for collecting, storing and transporting clinical specimens from rural areas and limited-resource settings to laboratory facilities, where viral infections can be more reliably diagnosed. Methods: The seroprevalence and virological characterization of hepatitis B virus (HBV) and hepatitis C virus (HCV), as well as human retroviruses (HIV-1, HIV-2, human T-cell leukaemia virus type 1 [HTLV-1] and human T-cell leukaemia virus type 2 [HTLV-2]), were investigated in clinical specimens collected from DBS in Ghana. Results: A total of 305 consecutive DBS were collected. A high prevalence of chronic HBV (8.5%) and occult hepatitis B (14.2%) was found, whereas rates were lower for HIV-1, HTLV-1 and HCV (3.2%, 1.3% and 0.6%, respectively). HIV-2 and HTLV-2 were absent. CRF02_AG was the predominant HIV-1 subtype, whereas genotype E was the most frequent HBV variant. Conclusions: DBS are helpful in the diagnosis and virological characterization of hepatitis and retrovirus infections in resource-limited settings. The high rate of hepatitis B in Ghana, either overt or occult, is noteworthy and confirms recent findings from other sub-Saharan countries. This should encourage close clinical follow up and antiviral treatment assessment in this population, as well as universal HBV vaccine campaigns.
Este ítem aparece en la(s) siguiente(s) colección(es)
Mostrando ítems relacionados por Título, autor o materia.
Mendoza, Carmen de; Roc, Lourdes; Benito, Rafael; Reina, Gabriel; Ramos, José M.; Gómez, Cesar; Soriano, Vicente (1); Corral, Octavio Jorge (1); ...et al.; Gómez-Gallego, Felix (1) (BMC Invectious Diseases, 09/08/2019)Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ...
Espigares Pinazo, Manuel Jesús (1); Bautista Vallejo, José Manuel (Educatio Siglo XXI, 11/2018)Este estudio presenta la aplicación de procesos automatizados de análisis a objetos digitales de aprendizaje musical online, mediados por una plataforma telemática. A nivel teórico, se basa en la aplicación de los principios ...
Aguilera, Antonio; Rodríguez-Calviño, Javier; Mendoza, Carmen de; Soriano, Vicente (1) (European Journal of Gastroenterology & Hepatology, 09/2018)Background The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals ...