Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
Autor:
Roc, Lourdes
; Mendoza, Carmen de
; Fernández-Alonso, Miriam
; Reina, Gabriel
; Soriano, Vicente (1)
; Rodriguez, C.
; ...et al.
; Corral, Octavio Jorge (1)
; Gómez-Gallego, Felix (1)
Fecha:
08/2019Palabra clave:
Tipo de Ítem:
Articulo Revista IndexadaDirección web:
https://journals.sagepub.com/doi/10.1177/2049936119868028
Resumen:
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor–recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain.
Este ítem aparece en la(s) siguiente(s) colección(es)
Estadísticas de uso
Año |
2012 |
2013 |
2014 |
2015 |
2016 |
2017 |
2018 |
2019 |
2020 |
2021 |
2022 |
Vistas |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
42 |
73 |
33 |
19 |
Descargas |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
HTLV-1 infection in solid organ transplant donors and recipients in Spain
Mendoza, Carmen de; Roc, Lourdes; Benito, Rafael; Reina, Gabriel; Ramos, José M.; Gómez, Cesar; Soriano, Vicente (1); Corral, Octavio Jorge (1); ...et al.; Gómez-Gallego, Felix (1) (BMC Invectious Diseases, 09/08/2019)Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ... -
Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
Mendoza, Carmen de; Pirón, María; González, Rocío; Jiménez, Ana; Caballero, Estrella; Roc, Lourdes; Benito, Rafael; Soriano, Vicente (1); Corral, Octavio Jorge (1); ...et al.; Gómez-Gallego, Felix (1) (Open Forum Infectious Diseases, 02/2019)Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late ... -
HIV co-infection in HTLV-1 carriers in Spain
Mendoza, Carmen de; Caballero, Estrella; Aguilera, Antonio; Benito, Rafael; Maciá, Dolores; García-Costa, Juan; Soriano, Vicente (1); Corral, Octavio Jorge (1); Gómez-Gallego, Felix (1); ...et al.; Morano, Luis (Virus Research, 06/2019)Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. ...