In numerous scientific and engineering domains, fractional-order derivatives and integral operators are frequently used to represent many complex phenomena. They also have numerous practical applications in the area of fixed point iteration. In this article, we introduce the notion of generalized Meir-Keeler-Khan-Rational type (ψ − α)-contraction mapping and propose fixed point results in partial metric spaces. Our proposed results extend, unify, and generalize existing findings in the literature. In regards to applicability, we provide evidence for the existence of a solution for the fractional-order differential operator. In addition, the solution of the integral equation and its uniqueness are also discussed. Finally, we conclude that our results are superior and generalized as compared to the existing ones.