The lung is one of the prime respiratory organs in human physiology, and its abnormality will severely disrupt the respiratory system. Lung Nodule (LN) is one of the abnormalities, and early screening and treatment are necessary to reduce its harshness. The proposed work aims to implement the Convolutional-Neural-Network (CNN) segmentation methodology to extract the LN in various lung CT slices, such as axial, coronal, and sagittal planes. This work consists of the following phases; (i) Image collection and pre-processing, (ii) Ground-truth generation, (iii) CNN-supported segmentation, and (iv) Performance evaluation and validation. In this work, the merit of pre-trained CNN segmentation schemes is verified using (i) One-fold training and (ii) Two-fold training methods. The test images for this study are collected from The Cancer Imaging Archive (TCIA) database. The experimental investigation is executed using Python®, and the outcome of this study confirms that the VGG-SegNet helps to get better values of Jaccard (>88%), Dice (>93%), and Accuracy (>96%) compared to other CNN methods.