This paper presents and reflects upon the training course organized by the OpenMed project, aimed at building capacity in Open Educational Resources (OER) and Open Education approaches across universities from the South Mediterranean, namely in Egypt, Jordan, Lebanon, Morocco and Palestine. The course, which is currently being piloted among 10 universities, represents an example of an intercultural and multilingual learning experience, both from the way in which it was conceived and developed, to the way it is actually being delivered. In this paper, we reflect on the challenges and benefits of adopting such an open approach towards intercultural learning.