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Hepatitis delta in patients with resolved hepatitis B virus infection

dc.contributor.authorAguilera, Antonio
dc.contributor.authorRodríguez-Calviño, Javier
dc.contributor.authorMendoza, Carmen de
dc.contributor.authorSoriano, Vicente
dc.date2018-09
dc.date.accessioned2019-01-22T12:09:36Z
dc.date.available2019-01-22T12:09:36Z
dc.identifier.issn1473-5687
dc.identifier.urihttps://reunir.unir.net/handle/123456789/7677
dc.description.abstractBackground The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections? Methods We tested for HDV-antibodies 406 individuals with markers of past HBV exposure. Results Overall, 20 (4.9%) were reactive for HDV-antibodies. All were negative for serum HDV-RNA, including four with elevated liver enzymes. Conclusion These results support the current policy of screening for hepatitis delta only in HBsAg+ individuals.es_ES
dc.language.isoenges_ES
dc.publisherEuropean Journal of Gastroenterology & Hepatologyes_ES
dc.relation.ispartofseries;vol. 30, nº 9
dc.rightsclosedAccesses_ES
dc.subjecthepatitis Bes_ES
dc.subjecthepatitis Ces_ES
dc.subjecthepatitis deltaes_ES
dc.subjectHIVes_ES
dc.subjectoccult hepatitises_ES
dc.subjectJCRes_ES
dc.subjectScopuses_ES
dc.titleHepatitis delta in patients with resolved hepatitis B virus infectiones_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1097/MEG.0000000000001187


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