Scientific achievements related to brain processes provide innovation and improvements in students' learning. The aim of this study was to analyse, relate, and compare learning strategies and academic performance of students from a neuropsychological perspective. For this, we applied the ACRA scale to 438 students to evaluate learning strategies such as acquisition, codification, retrieval and information processing support. Further, we analysed the influence of these strategies on academic performance. The results reveal that, with respect to academic performance, the students show lower scores on acquisition strategies and retrieval compared with the others, and they show more difficulties in Language and Chemistry and Physics. We found that the use of strategies was related to enhanced academic performance for all the students. We also found differences in the use of all strategies depending on academic performance. Thus, we propose an innovative, neuropsychological and technological intervention program that focuses on learning strategies.