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dc.contributor.authorCoullaut-Valera, R
dc.contributor.authorArbaiza, I
dc.contributor.authorBajo, Ricardo (1)
dc.contributor.authorArrue, R
dc.contributor.authorLópez, ME
dc.contributor.authorCollaut-Valera, J
dc.contributor.authorCorreas, A
dc.contributor.authorLópez-Sanz, D
dc.contributor.authorMaestú, Fernando
dc.contributor.authorPapo, D
dc.description.abstractDrug abusers typically consume not just one but several types of drugs, starting from alcohol and marijuana consumption, and then dramatically lapsing into addiction to harder drugs, such as cocaine, heroin, or amphetamine. The brain of drug abusers presents various structural and neurophysiological abnormalities, some of which may predate drug consumption onset. However, how these changes translate into modifications in functional brain connectivity is still poorly understood. To characterize functional connectivity patterns, we recorded Electroencephalogram (EEG) activity from 21 detoxified drug abusers and 20 age-matched control subjects performing a simple counting task and at rest activity. To evaluate the cortical brain connectivity network we applied the Synchronization Likelihood algorithm. The results showed that drug abusers had higher synchronization levels at low frequencies, mainly in the. band (48Hz) between frontal and posterior cortical regions. During the counting task, patients showed increased synchronization in the beta (14-35 Hz), and. (35-45 Hz) frequency bands, in fronto-posterior and interhemispheric temporal regions. Taken together ` slow-down' at rest and task-related 'over-exertion' could indicate that the brain of drug abusers is suffering from a premature form of ageing. Future studies will clarify whether this condition can be reversed following prolonged periods of abstinence.es_ES
dc.publisherInternational Journal of Neural Systemses_ES
dc.relation.ispartofseries;vol. 24, nº 1
dc.subjectpolydrug usees_ES
dc.subjectresting statees_ES
dc.subjectfunctional connectivityes_ES
dc.titleDrug polyconsumption is associated with increased synchronization of brain electrical-activity at rest and in a counting taskes_ES
dc.typeArticulo Revista Indexadaes_ES

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