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    Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study

    Autor: 
    López, María Eugenia
    ;
    Bruna, Ricardo
    ;
    Aurtenetxe, Sara
    ;
    Pineda-Pardo, José Ángel
    ;
    Marcos, Alberto
    ;
    Arrazola, Juan
    ;
    Reinoso, Ana Isabel
    ;
    Montejo, Pedro
    ;
    Bajo, Ricardo (1)
    ;
    Maestú, Fernando
    Fecha: 
    10/2014
    Palabra clave: 
    alpha band; anterior cingulate; functional connectivity; MEG; mild cognitive impairment; phase locking value; JCR; Scopus
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/5611
    DOI: 
    http://dx.doi.org/10.1523/JNEUROSCI.0964-14.2014
    Dirección web: 
    http://www.jneurosci.org/content/34/44/14551
    Open Access
    Resumen:
    People with mild cognitive impairment (MCI) show a high risk to develop Alzheimer's disease (AD; Petersen et al., 2001). Nonetheless, there is a lack of studies about how functional connectivity patterns may distinguish between progressive (pMCI) and stable (sMCI) MCI patients. To examine whether there were differences in functional connectivity between groups, MEG eyes-closed recordings from 30 sMCI and 19 pMCI subjects were compared. The average conversion time of pMCI was 1 year, so they were considered as fast converters. To this end, functional connectivity in different frequency bands was assessed with phase locking value in source space. Then the significant differences between both groups were correlated with neuropsychological scores and entorhinal, parahippocampal, and hippocampal volumes. Both groups did not differ in age, gender, or educational level. pMCI patients obtained lower scores in episodic and semantic memory and also in executive functioning. At the structural level, there were no differences in hippocampal volume, although some were found in left entorhinal volume between both groups. Additionally, pMCI patients exhibit a higher synchronization in the alpha band between the right anterior cingulate and temporo-occipital regions than sMCI subjects. This hypersynchronization was inversely correlated with cognitive performance, both hippocampal volumes, and left entorhinal volume. The increase in phase synchronization between the right anterior cingulate and temporo-occipital areas may be predictive of conversion from MCI to AD.
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