Mostrando ítems 1-20 de 34

    • Bulevirtide in the Treatment of Hepatitis Delta: Drug Discovery, Clinical Development and Place in Therapy 

      Soriano, Vicente; Moreno-Torres, Víctor; Treviño, Ana; Corral, Octavio Jorge; de Mendoza, Carmen (Drug Design, Development and Therapy, 2023)
      It has been ten years since the identification of NTCP as the cell surface receptor for HBV and HDV entry into hepatocytes. The search for molecules interfering with the binding of NTCP and HBV/HDV led to design bulevirtide ...
    • Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain 

      Mendoza, Carmen de; Pirón, María; González, Rocío; Jiménez, Ana; Caballero, Estrella; Roc, Lourdes; Benito, Rafael; Soriano, Vicente ; Corral, Octavio Jorge ; ...et al.; Gómez-Gallego, Felix (Open Forum Infectious Diseases, 02/2019)
      Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late ...
    • Effect of childhood pneumococcal vaccination and beta-lactam antibiotic use on the incidence of invasive pneumococcal disease in the adult population 

      Fernández Chávez, Abelardo; García Comas, Luis; Sanz Moreno, Juan Carlos; Canton Moreno, Rafael; Corral, Octavio Jorge ; Aranaz Andrés, Jesús María (European journal of clinical microbiology&infectious diseases, 2021)
      Describe the incidence of invasive pneumococcal disease (IPD) in serotypes with reduced antibiotic sensitivity to penicillin (RAS-Pen) in adults over 59 years of age and its association with childhood anti-pneumococcal ...
    • Envisioning a hepatitis delta cure with new antivirals 

      Soriano, Vicente ; Mendoza, Carmen de; Barreiro, Pablo; Treviño, Ana ; Corral, Octavio Jorge (Future Medicine Ltd., 2021)
      Envisioning a hepatitis delta cure with new antivirals
    • Genetic signature detected in T cell receptors from patients with severe COVID-19 

      Corpas, Manuel; de Mendoza, Carmen; Moreno-Torres, Víctor; Pintos, Ilduara; Seoane, Pablo; Perkins, James R.; Ranea, Juan A.G.; Fatumo, Segun; Korcsmaros, Tamas; Martín-Villa, José Manuel; Barreiro, Pablo; Corral, Octavio Jorge (iScience, 2023)
      Characterization of host genetic factors contributing to COVID-19 severity promises advances on drug discovery to fight the disease. Most genetic analyses to date have identified genome-wide significant associations involving ...
    • Hepatitis C hospitalizations in Spain and impact of new curative antiviral therapies 

      Ramos-Rincón, José-Manuel; Pinargote-Celorio, Héctor; de Mendoza, Carmen; Ramos-Belinchón, Clara; Barreiro, Pablo; Gómez-Gallego, Felix; Corral, Octavio Jorge; Soriano, Vicente (Journal of Viral Hepatitis, 2022)
      Chronic hepatitis C virus (HCV) infection is major cause of decompensated cirrhosis and liver cancer. The advent of curative new antiviral therapies since year 2015 has dramatically improved the prognosis of HCV patients. ...
    • Hepatitis Delta Estimates in the United States Revisited 

      Soriano, Vicente ; Gómez-Gallego, Felix ; Corral, Octavio Jorge (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 30/10/2019)
      To the Editor—We read with interest the article by Patel and colleagues [1], which reported an unexpected 33% prevalence of anti–hepatitis delta virus antibodies (anti-HDV-Abs) in a large and representative US household ...
    • HIV co-infection in HTLV-1 carriers in Spain 

      Mendoza, Carmen de; Caballero, Estrella; Aguilera, Antonio; Benito, Rafael; Maciá, Dolores; García-Costa, Juan; Soriano, Vicente ; Corral, Octavio Jorge ; Gómez-Gallego, Felix ; ...et al.; Morano, Luis (Virus Research, 06/2019)
      Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. ...
    • HTLV-1 infection in solid organ transplant donors and recipients in Spain 

      Mendoza, Carmen de; Roc, Lourdes; Benito, Rafael; Reina, Gabriel; Ramos, José M.; Gómez, Cesar; Soriano, Vicente ; Corral, Octavio Jorge ; ...et al.; Gómez-Gallego, Felix (BMC Invectious Diseases, 09/08/2019)
      Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ...
    • Impact of COVID-19 pandemic in surgical training of Junior Residents in general surgery 

      García-Quijada García, Javier; Sanz Muñoz, Paloma; Salazar Carrasco, Andrea; Corral, Octavio Jorge; Delgado Millán, Miguel Ángel (Heliyon, 2022)
      Background: The pandemic caused by SARS-CoV2 has had a huge impact on our health system. Due to both cancellation of elective surgery and restructuring in departments at most medical centers, surgical residents face a ...
    • Impact of potent nucleos(t)ide therapy on hepatitis B hospitalisations in Spain 

      Ramos-Rincón, José-Manuel; Pinargote-Celorio, Héctor; de Mendoza, Carmen; Ramos-Belinchón, Clara; Barreiro, Pablo; Treviño, Ana; Corral, Octavio Jorge; Soriano, Vicente (Alimentary Pharmacology and Therapeutics, 2023)
      Background: Chronic hepatitis B virus (HBV) infection is a major cause of decompensated cirrhosis and liver cancer worldwide. Newborn HBV vaccination was implemented in Spain two decades ago, and potent oral antivirals ...
    • Impact of previous macrolide use on invasive pneumococcal disease due to erythromycin-resistant serotypes in adults over 59 years of age 

      Fernández Chávez, Abelardo; García Comas, Luis; Manzano Espinosa, Luis; Yuste Lobo, Jose; Corral, Octavio Jorge; Aranaz Andrés, Jesús María (European Journal of Clinical Microbiology and Infectious Diseases, 2022)
      The major goals of the study were to describe the invasive pneumococcal disease (IPD) cases due to erythromycin-resistant serotypes and to evaluate the association between these cases and recent macrolide use in individuals ...
    • Impact of the COVID-19 pandemic on hospital admissions due to viral hepatitis in Spain 

      Ramos-Rincón, José-Manuel; Pinargote-Celorio, Héctor; de Mendoza, Carmen; Ramos-Belinchón, Clara; Moreno-Torres, Víctor; Treviño, Ana; Barreiro, Pablo; Corral, Octavio Jorge; Soriano, Vicente (Journal of Clinical Virology, 2023)
      Background: Before the advent of COVID-19 vaccines, hospitalizations due to SARS-CoV-2 infection during 2020 collapsed most medical centers worldwide. Disruptions in health care for clinical conditions other than COVID-19 ...
    • International outbreak of monkeypox in men having sex with men 

      Soriano, Vicente; Corral, Octavio Jorge (AIDS Reviews, 2022)
      On May 17, seven patients with monkeypox were reported in the United Kingdom (Mahase E. BMJ 2022). Since that time, more than 400 cases have been reported in 20 non-African countries, including Spain, Portugal, Italy, ...
    • Is SARS-CoV-2 the only cause of long-COVID? 

      Pintos, Ilduara; Moreno-Torres, Víctor; Ibánez-Estéllez, Fatima; Corrales-Rodriguez, Pilar; Treviño, Ana; Corpas, Manuel; Corral, Octavio Jorge; Soriano, Vicente; de Mendoza, Carmen (AIDS Reviews, 2022)
      Around 10% of adults infected with SARS-CoV-2 that survive a first episode of COVID-19 appear to experience long-term clinical manifestations. The signs and symptoms of this post-acute COVID-19 syndrome (PACS) include ...
    • Keeping alive enterprises while embracing unprecedented COVID-19 restrictions 

      Soriano, Vicente ; Corral, Octavio Jorge (Therapeutic Advances in Infectious Disease, 04/2020)
      COVID-19 is rapidly expanding globally, with more than 1,800,000 cases and 105,000 deaths to date (April 11, 2020) (www.worldometers.info). The WHO upgrade to pandemic, the emergency declaration in the United States, and ...
    • Late presentation of human T-lymphotropic virus type 1 infection in Spain reflects suboptimal testing strategies: on behalf of the Human T-lymphotropic Virus (HTLV) Spanish Network 

      de Mendoza, Carmen; Pérez, Leire; Fernández-Ruiz, Mario; Pena, María José; Ramos, José Manuel; Richart, Alberto; Pirón, María; Rando, Ariadna; Miró, Elisenda; Reina, Gabriel; Encinas, Beatriz; Rojo, Silvia; Rodriguez-Iglesias, Antonio Manuel; Benito, Rafael; Aguilera, Antonio; Treviño, Ana; Corral, Octavio Jorge; Soriano, Vicente (International Journal of Infectious Diseases, 2022)
      Objectives: Although only 10% of persons infected with human T-lymphotropic virus type 1 (HTLV-1) may develop virus-associated illnesses over their lifetime, missing the earlier diagnosis of asymptomatic carriers frequently ...
    • Liver cancer and hepatic decompensation events in patients hospitalized with viral hepatitis in Spain 

      Ramos-Rincón, José-Manuel; Pinargote-Celorio, Héctor; de Mendoza, Carmen; Ramos-Belinchón, Clara; Barreiro, Pablo; Treviño, Ana; Corral, Octavio Jorge; Soriano, Vicente (Hepatology International, 2022)
      Background: Chronic viral hepatitis B, C, and D are the main causes of decompensated cirrhosis and liver cancer worldwide. Newborn HBV vaccination was implemented more than 2 decades ago in most EU countries. Furthermore, ...
    • Longer Life Expectancy but still Accelerating Aging in HIV Patients under Antiretroviral Therapy 

      Soriano, Vicente ; Corral, Octavio Jorge (AIDS Reviews, 10/2018)
      The current goal of HIV treatment is sustained undetectable plasma viremia.
    • Main differences between the first and second waves of COVID-19 in Madrid, Spain 

      Soriano, Vicente ; Ganado-Pinilla, Pilar ; Sánchez-Santos, Miguel ; Gómez-Gallego, Felix ; Barreiro, Pablo; de Mendoza, Carmen; Corral, Octavio Jorge (International journal of infectious diseases, 2021)
      Background: The emergence and rapid global spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) represents a major challenge to health services, and has disrupted social and economic activities worldwide. ...