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The unexpected high prevalence of HBV subgenotype D4 in patients with chronic hepatitis B in Galicia, a northwestern Spanish region, reflects strong links with Latin America
dc.contributor.author | Trastoy, Rocío | |
dc.contributor.author | González-Alba, José María | |
dc.contributor.author | Soriano, Vicente | |
dc.contributor.author | Rodríguez-Calviño, José Javier | |
dc.contributor.author | de Mendoza, Carmen | |
dc.contributor.author | Costa, José Javier | |
dc.contributor.author | Cea, María | |
dc.contributor.author | Barbeito, Gema | |
dc.contributor.author | Corral, Octavio Jorge | |
dc.contributor.author | Gómez-Gallego, Felix | |
dc.contributor.author | Pérez del Molino, María Luisa | |
dc.contributor.author | Carlos Galán, Juan | |
dc.contributor.author | Aguilera, Antonio | |
dc.date | 2022 | |
dc.date.accessioned | 2023-01-18T13:46:39Z | |
dc.date.available | 2023-01-18T13:46:39Z | |
dc.identifier.issn | 13866532 | |
dc.identifier.uri | https://reunir.unir.net/handle/123456789/14018 | |
dc.description.abstract | Background: Hepatitis B virus (HBV) comprises 9 genotypes and multiple subgenotypes that depict differences in geographic distribution, clinical outcome and response to antiviral therapy. However, the molecular epidemiology of HBV geno/subgenotypes is globally scarce. In Spain, HBV genotype D seems to be more prevalent in the northwestern regions compared to the rest of the country for unclear reasons. Methods: HBV genotyping was performed using geno2pheno on a S gene fragment amplified from plasma collected from all chronic hepatitis B individuals attended at one reference hospital in Santiago de Compostela, the Galicia's capital town. Phylogenetic and phylogeographic analyses using a fragment of 345 bp were performed in all viremic specimens. To avoid misleading allocation as consequence of short fragment analysis, several bioinformatic controls were used. Results: A total of 320 individuals with persistent serum HBsAg+ and detectable HBV-DNA were seen between 2000 and 2016 (male 68.4%; median age, 52 years-old; native Spaniards 83.8%). HBV genotype distribution was as follows: A 15.3%; B 1.6%; C 2.5%; D 71.6%; E 3.1%; F 2.2%; G 3.1%; and H 0.6%. HBV genotype D was mostly represented by D4 and D2 subgenotypes (33.4% and 15% of total, respectively). Compared to chronic hepatitis B patients with genotypes B, C, E and G, HBV-D4 carriers tended to be older (54.2% had >50 years-old) and HBeAg-negative (85%). Moreover, 43% were female, 4.7% had cirrhosis, 10.2% hepatitis C and 6.4% HIV coinfection. Phylogenetic analyses could be performed on 82 HBV-D4 specimens; and 79 were confirmed as HBV-D4 using PhyML. Phylogeography using FasTree suggested at least two distinct introductions of HBV-D4 in Galicia, one from the Caribbean and South America, and another from India. Conclusions: HBV subgenotype D4 is the most prevalent HBV variant in chronic hepatitis B patients living in the northwest of Spain, representing 33.4% (107/320) of all chronic hepatitis B infections. This rate of HBV-D4 is among the highest reported worldwide. Epidemiological and phylogenetic analyses suggest a strong association with historical migrant exchanges with Latin America, and especially with the Caribbean basin. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Journal of Clinical Virology | es_ES |
dc.relation.ispartofseries | ;vol. 153 | |
dc.relation.uri | https://www.sciencedirect.com/science/article/pii/S1386653222001287?via%3Dihub | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | genotypes | es_ES |
dc.subject | hepatitis B | es_ES |
dc.subject | molecular epidemiology | es_ES |
dc.subject | philogeography | es_ES |
dc.subject | Spain | es_ES |
dc.subject | subgenotypes | es_ES |
dc.subject | viral diversity | es_ES |
dc.subject | Scopus | es_ES |
dc.subject | JCR | es_ES |
dc.title | The unexpected high prevalence of HBV subgenotype D4 in patients with chronic hepatitis B in Galicia, a northwestern Spanish region, reflects strong links with Latin America | es_ES |
dc.type | Articulo Revista Indexada | es_ES |
reunir.tag | ~ARI | es_ES |
dc.identifier.doi | https://doi.org/10.1016/j.jcv.2022.105195 |
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