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    Saliva in the Diagnosis of COVID-19: A Review and New Research Directions

    Autor: 
    Leci Fernandes, Larissa
    ;
    Bordallo Pacheco, Valeria
    ;
    Borges, Leandro
    ;
    Athwal, H.K.
    ;
    de Paula Eduardo, F.
    ;
    Bezinelli, L.
    ;
    Jiménez, Manuel
    ;
    Dame-Teixeira, N.
    ;
    Lombaert, I.M.A.
    ;
    Heller, Debora
    Fecha: 
    12/2020
    Palabra clave: 
    coronavirus; coronavirus infections; biomarkers; COVID-19 diagnostic testing; saliva diagnosis; severe acute respiratory syndrome coronavirus 2; JCR; Scopus
    Revista / editorial: 
    Journal of Dental Research
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/11107
    DOI: 
    http://doi.org/10.1177/0022034520960070
    Dirección web: 
    https://journals.sagepub.com/doi/10.1177/0022034520960070
    Open Access
    Resumen:
    This review presents literature that highlights saliva's utility as a biofluid in the diagnosis and monitoring of COVID-19. A systematic search was performed in 5 electronic databases (PubMed, Embase, LILACS, Scopus, and Web of Science). Studies were eligible for inclusion if they assessed the potential diagnostic value and/or other discriminatory properties of biological markers in the saliva of patients with COVID-19. As of July 22, 2020, a total of 28 studies have investigated the presence of SARS-CoV-2 RNA in saliva. Several of those studies confirmed reliable detection of SARS-CoV-2 in the saliva of patients with COVID-19. Saliva offered sensitivity and specificity for SARS-CoV-2 detection comparable to that of the current standard of nasopharyngeal and throat swabs. However, the utility of saliva in diagnosing COVID-19 infection remains understudied. Clinical studies with larger patient populations that measure recordings at different stages during the disease are still necessary to confirm the accuracy of COVID-19 diagnosis with saliva. Nevertheless, the utility of saliva as a diagnostic tool opens the possibility of using rapid and less invasive diagnostic strategies by targeting bioanalytes rather than the pathogen.
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