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    • Revista IJIMAI
    • 2012
    • vol. 1, nº 5, june 2012
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    • Revista IJIMAI
    • 2012
    • vol. 1, nº 5, june 2012
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    Improved Differential Evolution Algorithm for Parameter Estimation to Improve the Production of Biochemical Pathway

    Autor: 
    Khim Chong, Chuii
    ;
    Saberi Mohamad, Mohd
    ;
    Deris, Safaai
    ;
    Shahir Shamsir, Mohd
    ;
    Wen Choon, Yee
    ;
    En Chai, Lian
    Fecha: 
    06/2012
    Palabra clave: 
    parameter estimation; differential evolution; algorithm; kalman filter; simulation; IJIMAI
    Tipo de Ítem: 
    article
    URI: 
    https://reunir.unir.net/handle/123456789/9575
    DOI: 
    http://dx.doi.org/10.9781/ijimai.2012.153
    Dirección web: 
    https://www.ijimai.org/journal/node/223
    Open Access
    Resumen:
    This paper introduces an improved Differential Evolution algorithm (IDE) which aims at improving its performance in estimating the relevant parameters for metabolic pathway data to simulate glycolysis pathway for yeast. Metabolic pathway data are expected to be of significant help in the development of efficient tools in kinetic modeling and parameter estimation platforms. Many computation algorithms face obstacles due to the noisy data and difficulty of the system in estimating myriad of parameters, and require longer computational time to estimate the relevant parameters. The proposed algorithm (IDE) in this paper is a hybrid of a Differential Evolution algorithm (DE) and a Kalman Filter (KF). The outcome of IDE is proven to be superior than Genetic Algorithm (GA) and DE. The results of IDE from experiments show estimated optimal kinetic parameters values, shorter computation time and increased accuracy for simulated results compared with other estimation algorithms.
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    Nombre: IJIMAI20121_5_3_0.pdf
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