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    Differential Patterns of Connectivity in Progressive Mild Cognitive Impairment

    Autor: 
    Bajo, Ricardo
    ;
    Castellanos, Nazareth
    ;
    Cuesta, Pablo
    ;
    Aurtenetxe, Sara
    ;
    Garcia-Prieto, Juan
    ;
    Gil-Gregorio, Pedro
    ;
    del pozo, Francisco
    ;
    Maestú, Fernando
    Fecha: 
    05/2012
    Palabra clave: 
    alzheimer's disease; functional connectivity; magnetoencephalography; memory task; mild cognitive impairment; progressive mild cognitive impairment; stable mild cognitive impairment; synchronization likelihood; Scopus; JCR
    Revista / editorial: 
    Brain Connectivity
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/6153
    DOI: 
    https://doi.org/10.1089/brain.2011.0069
    Dirección web: 
    http://online.liebertpub.com/doi/abs/10.1089/brain.2011.0069?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
    Resumen:
    It is now widely accepted that Alzheimer's disease is characterized by a functional disconnection between brain regions. The disease appears to begin up to decades prior to clinical diagnosis. Therefore, in the present study, we combined magnetoencephalography, a memory task, and functional connectivity analysis in mild cognitive impairment subjects in order to identify functional connectivity patterns that could characterize subjects who would eventually go on to develop the disease. We monitored 19 subjects and finally 5 of them developed Alzheimer's disease. These progressive patients showed a differential profile of functional connectivity values compared with those patients who remained stable over time. Specifically there were higher synchronization values over the parieto-occipital region in α and β frequency bands. The involvement of this brain region in amyloid-β accumulation and its possible association with hyper-synchronization are also discussed.
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