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dc.contributor.authorLópez, María Eugenia
dc.contributor.authorCuesta, Pablo
dc.contributor.authorGarcés, Pilar
dc.contributor.authorCastellanos, Nazareth
dc.contributor.authorAurtenetxe, Sara
dc.contributor.authorBajo, Ricardo
dc.contributor.authorMarcos, Alberto
dc.contributor.authorDelgado, ML
dc.contributor.authorMontejo, Pedro
dc.contributor.authorLópez-Pantoja, JL
dc.contributor.authorMaestú, Fernando
dc.contributor.authorFernández, A
dc.description.abstractMild cognitive impairment (MCI) has been described as an intermediate stage between normal aging and dementia. Previous studies characterized the alterations of brain oscillatory activity at this stage, but little is known about the differences between single and multidomain amnestic MCI patients. In order to study the patterns of oscillatory magnetic activity in amnestic MCI subtypes, a total of 105 subjects underwent an eyes-closed resting-state magnetoencephalographic recording: 36 healthy controls, 33 amnestic single domain MCIs (a-sd-MCI), and 36 amnestic multidomain MCIs (a-md-MCI). Relative power values were calculated and compared among groups. Subsequently, relative power values were correlated with neuropsychological tests scores and hippocampal volumes. Both MCI groups showed an increase in relative power in lower frequency bands (delta and theta frequency ranges) and a decrease in power values in higher frequency bands (alpha and beta frequency ranges), as compared with the control group. More importantly, clear differences emerged from the comparison between the two amnestic MCI subtypes. The a-md-MCI group showed a significant power increase within delta and theta ranges and reduced relative power within alpha and beta ranges. Such pattern correlated with the neuropsychological performance, indicating that the a-md-MCI subtype is associated not only with a "slowing" of the spectrum but also with a poorer cognitive status. These results suggest that a-md-MCI patients are characterized by a brain activity profile that is closer to that observed in Alzheimer disease. Therefore, it might be hypothesized that the likelihood of conversion to dementia would be higher within this subtype.es_ES
dc.relation.ispartofseries;vol. 36, nº 3
dc.subjectmild cognitive impairmentes_ES
dc.subjectrelative poweres_ES
dc.subjectneuropsychological performancees_ES
dc.titleMEG spectral analysis in subtypes of mild cognitive impairmentes_ES
dc.typeArticulo Revista Indexadaes_ES

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