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Predictors of Hepatitis C Treatment Failure After Using Direct-Acting Antivirals in People Living With Human Immunodeficiency Virus
(Open Forum Infectious Diseases, 2019-03)
Background. Little is known about the influence of ongoing barriers to care in the persistence of hepatitis C virus (HCV) viremia after treatment with direct-acting antivirals (DAAs) among people living with human ...
Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2
(Journal of Infectious Diseases, 2020-06)
Background: HIV-1 and HIV-2 differ in their antiretroviral (ARV) susceptibilities and drug resistance mutations (DRMs). Methods: We analyzed published HIV-2 pol sequences to identify HIV-2 treatment-selected mutations ...
Gene editing for HIV cure at the edge
(AIDS Reviews, 2019-01)
Whereas advances in antiretroviral therapy and its widespread use are providing huge benefits in terms of prventing new HIV transmissions to uninfected individuals as well as halting disease progression in patients, the ...
Occult hepatitis B and HIV infection
(European Journal of Gastroenterology & Hepatology, 2019-11)
Introduction Occult hepatitis B virus (HBV) infection, so-called occult B infection (OBI), is defined by the recognition of HBV-DNA in the absence of serum hepatitis B surface antigen (HBsAg). The HBV-DNA genome in OBI is ...
Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain
(AIDS, 2019-11-15)
Background: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all ...
Long-acting antiretroviral therapy
(Nature Materials, 2020-08-01)
Nanoformulations of cabotegravir prodrugs have been developed to prolong the pharmacokinetics of the
antiretroviral agent. They can be present in the plasma of mice and non-human primates for a year following
a single injection.
Update of the statements on biology and clinical impact of occult hepatitis B virus infection
(Journal of Hepatology, 2019-08)
In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were ...
Multiple recombinant events in human T-cell Leukemia virus Type 1: complete sequences of recombinant African strains
(Emerging Microbes and Infections, 2020-01-01)
Africa is the largest endemic area for HTLV-1, with many molecular genotypes. We previously demonstrated that some strains from North Africa (a-NA clade) originated from a recombinant event between Senegalese and West ...
Impact of New Coronavirus Epidemics on HIV-Infected Patients
(AIDS Reviews, 2020)
Since the first report of a cluster of pneumonia cases in Wuhan (China) at the end of 2019 due to a new airborne highly transmissible coronavirus known as SARS-CoV-2, large-scale spreading has rapidly become a global ...
COVID-19 Comes 40 Years After AIDS - Any Lesson?
(AIDS Reviews, 2020-06)
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has hit health-care systems and societies in an unprecedented manner. In 1981, the first cases of AIDS were reported and wide diagnostic ...