• A Key Action Plan for EDUCATION in a Global Crisis 

      Soriano, Vicente ; Cardona, Pablo ; Corpas, Manuel (Lecture notes in educational technology, 2021)
      Wars and natural disasters cause profound disturbances in human lives and social services. Historically, large pandemics have hit communities triggering rapid transformation of societies. The global COVID-19 outbreak has ...
    • Editorial: Personal Genomes: Accessing, Sharing, and Interpretation 

      Corpas, Manuel ; Beck, Stephan; Glusman, Gustavo; Shabani, Mahsa (Frontiers in Genetics, 2021)
      Over the past few years we have witnessed a number of advances in the personal genomics space including (a) more affordable sequencing technology, (b) mainstreaming of genomics in healthcare systems, (c) augmented sharing ...
    • Genetic signature detected in T cell receptors from patients with severe COVID-19 

      Corpas, Manuel; de Mendoza, Carmen; Moreno-Torres, Víctor; Pintos, Ilduara; Seoane, Pablo; Perkins, James R.; Ranea, Juan A.G.; Fatumo, Segun; Korcsmaros, Tamas; Martín-Villa, José Manuel; Barreiro, Pablo; Corral, Octavio Jorge (iScience, 2023)
      Characterization of host genetic factors contributing to COVID-19 severity promises advances on drug discovery to fight the disease. Most genetic analyses to date have identified genome-wide significant associations involving ...
    • Implementation of individualised polygenic risk score analysis: a test case of a family of four 

      Corpas, Manuel; Megy, Karyn; Metastasio, Antonio; Lehmann, Edmund (BMC Medical Genomics, 2022)
      Background: Polygenic risk scores (PRS) have been widely applied in research studies, showing how population groups can be stratified into risk categories for many common conditions. As healthcare systems consider applying ...
    • Is SARS-CoV-2 the only cause of long-COVID? 

      Pintos, Ilduara; Moreno-Torres, Víctor; Ibánez-Estéllez, Fatima; Corrales-Rodriguez, Pilar; Treviño, Ana; Corpas, Manuel; Corral, Octavio Jorge; Soriano, Vicente; de Mendoza, Carmen (AIDS Reviews, 2022)
      Around 10% of adults infected with SARS-CoV-2 that survive a first episode of COVID-19 appear to experience long-term clinical manifestations. The signs and symptoms of this post-acute COVID-19 syndrome (PACS) include ...
    • Predictors of in-hospital mortality in HIV-infected patients with COVID-19 

      Moreno-Torres, Víctor; de Mendoza, Carmen; Martínez-Urbistondo, María; Mills, Patricia; Treviño, Ana; de la Fuente, Sara; Diaz de Santiago, Alberto; Calderon-Parra, Jorge; Pintos, Ilduara; Corpas, Manuel; Soriano, Vicente (QJM: An International Journal of Medicine, 2023)
      Background Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate. Aim: assessment of the mortality rate and ...
    • Transferability of genetic risk scores in African populations 

      Kamiza, Abram B; Toure, Sounkou M.; Vujkovic, Marijana; Machipisa, Tafadzwa; Soremekun, Opeyemi S.; Kintu, Christopher; Corpas, Manuel ; Pirie, Fraser; Young, Elizabeth; Gill, Dipender; Sandhu, Manjinder S.; Kaleebu, Pontiano; Nyirenda, Moffat; Motala, Ayesha A.; Chikowore, Tinashe; Fatumo, Segun (Nature Medicine, 2022)
      A new study reveals that polygenic scores for lipid traits derived from data of African American individuals have high predictive value in a South African Zulu cohort but are poor predictors in a cohort from Uganda, further ...
    • Whole Genome Interpretation for a Family of Five 

      Corpas, Manuel ; Megy, Karyn; Mistry, Vanisha; Metastasio, Antonio; Lehmann, Edmund (Frontiers in Genetics, 2021)
      Although best practices have emerged on how to analyse and interpret personal genomes, the utility of whole genome screening remains underdeveloped. A large amount of information can be gathered from various types of ...