Over the past few years we have witnessed a number of advances in the personal genomics space including (a) more affordable sequencing technology, (b) mainstreaming of genomics in healthcare systems, (c) augmented sharing of genomic data, and (d) increased demand for direct-to-consumer genetic testing. All of these developments have brought us closer to the long-awaited genomics revolution. This genomics revolution is not exempt from challenges, in part amplified by lack of standards (ethical, legal, and technological), slow translation of knowledge to the clinic, and unequal access of personal genome benefits for all.