• Mi Re-Unir
    Búsqueda Avanzada
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Ver ítem 
    •   Inicio
    • RESULTADOS DE INVESTIGACIÓN
    • Artículos Científicos WOS y SCOPUS
    • Ver ítem
    •   Inicio
    • RESULTADOS DE INVESTIGACIÓN
    • Artículos Científicos WOS y SCOPUS
    • Ver ítem

    Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults

    Autor: 
    Montes-De-oca-garcia, Adrián
    ;
    Corral-Perez, Juán
    ;
    Velazquez-Diaz, Daniel
    ;
    Perez-Bey, Alejandro
    ;
    Rebollo-Ramos, María
    ;
    Marin-Galindo, Alberto
    ;
    Gómez-Gallego, Felix
    ;
    Calderón, María
    ;
    Casals, Cristina
    ;
    Ponce-González, Jesús
    Fecha: 
    2022
    Palabra clave: 
    genetic association studies; cardiometabolic risk; metabolism; healthy lifestyle; PPARGC1A; caucasian; obesity; physical exercise; JCR; Scopus
    Revista / editorial: 
    Frontiers in Physiology
    Citación: 
    Montes-de-Oca-García, A., Corral-Pérez, J., Velázquez-Díaz, D., Perez-Bey, A., Rebollo-Ramos, M., Marín-Galindo, A., ... & Ponce-González, J. G. (2022). Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults. Frontiers in Physiology, 1507.
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/14233
    DOI: 
    https://doi.org/10.3389/fphys.2022.885185
    Dirección web: 
    https://www.frontiersin.org/articles/10.3389/fphys.2022.885185/full
    Open Access
    Resumen:
    This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C > T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 +/- 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C > T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (p = 0.045) and total energy expenditure (p = 0.024). A genotype*sex interaction was found in the QUICKI index (p = 0.016), with differences between CC and CT/TT in men (p = 0.049) and between men and women inside the CT/TT group (p = 0.049). Thus, the PPARGC1A gene rs8192678 C > T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C > T polymorphism on the QUICKI index.
    Mostrar el registro completo del ítem
    Ficheros en el ítem
    icon
    Nombre: influence_peroxisome_proliferator-activated.pdf
    Tamaño: 686.4Kb
    Formato: application/pdf
    Ver/Abrir
    Este ítem aparece en la(s) siguiente(s) colección(es)
    • Artículos Científicos WOS y SCOPUS

    Estadísticas de uso

    Año
    2012
    2013
    2014
    2015
    2016
    2017
    2018
    2019
    2020
    2021
    2022
    2023
    2024
    2025
    Vistas
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    84
    109
    66
    Descargas
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    0
    44
    62
    23

    Ítems relacionados

    Mostrando ítems relacionados por Título, autor o materia.

    • Influence of ace gene I/D polymorphism on cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet and physical activity in young adults 

      Montes-De-oca-garcia, Adrián; Perez-Bey, Alejandro; Velazquez-Diaz, Daniel; Corral-Perez, Juán; Opazo-Diaz, Edgardo; Rebollo-Ramos, María; Gómez-Gallego, Felix ; Cuenca-Garcia, Magdalena; Casals, Cristina; Ponce-González, Jesús (International journal of environmental research and public health, 2021)
      There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence ...
    • Susceptibility to hepatitis B virus infection in adults living in Spain 

      Soriano, Vicente; Aguilera, Antonio; Benito, Rafael; Gonzalez-Diez, Rocio; Miro, Elisenda; Liendo, Paloma; Rodriguez-Diaz, Juan Carlos; Cabezas, Teresa; Richart, Alberto; Ramos, José Manuel; Barea, Luisa; Alvarez, Carmen; Treviño, Ana; Gómez-Gallego, Felix; Corral, Octavio Jorge; de Mendoza, Carmen (Liver International, 2023)
      BackgroundA protective hepatitis B virus (HBV) vaccine has been available for four decades. Universal HBV vaccination of infants is recommended by the WHO since the 1990s. Furthermore, HBV immunization is advised for all ...
    • The unexpected high prevalence of HBV subgenotype D4 in patients with chronic hepatitis B in Galicia, a northwestern Spanish region, reflects strong links with Latin America 

      Trastoy, Rocío; González-Alba, José María; Soriano, Vicente ; Rodríguez-Calviño, José Javier; de Mendoza, Carmen; Costa, José Javier; Cea, María; Barbeito, Gema; Corral, Octavio Jorge ; Gómez-Gallego, Felix ; Pérez del Molino, María Luisa; Carlos Galán, Juan; Aguilera, Antonio (Journal of Clinical Virology, 2022)
      Background: Hepatitis B virus (HBV) comprises 9 genotypes and multiple subgenotypes that depict differences in geographic distribution, clinical outcome and response to antiviral therapy. However, the molecular epidemiology ...

    Mi cuenta

    AccederRegistrar

    ¿necesitas ayuda?

    Manual de UsuarioContacto: reunir@unir.net

    Listar

    todo Re-UnirComunidades y coleccionesPor fecha de publicaciónAutoresTítulosPalabras claveTipo documentoTipo de accesoEsta colecciónPor fecha de publicaciónAutoresTítulosPalabras claveTipo documentoTipo de acceso






    Aviso Legal Política de Privacidad Política de Cookies Cláusulas legales RGPD
    © UNIR - Universidad Internacional de La Rioja
     
    Aviso Legal Política de Privacidad Política de Cookies Cláusulas legales RGPD
    © UNIR - Universidad Internacional de La Rioja