Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults
Autor:
Montes-De-oca-garcia, Adrián
; Corral-Perez, Juán
; Velazquez-Diaz, Daniel
; Perez-Bey, Alejandro
; Rebollo-Ramos, María
; Marin-Galindo, Alberto
; Gómez-Gallego, Felix
; Calderón, María
; Casals, Cristina
; Ponce-González, Jesús
Fecha:
2022Palabra clave:
Revista / editorial:
Frontiers in PhysiologyCitación:
Montes-de-Oca-García, A., Corral-Pérez, J., Velázquez-Díaz, D., Perez-Bey, A., Rebollo-Ramos, M., Marín-Galindo, A., ... & Ponce-González, J. G. (2022). Influence of Peroxisome Proliferator-Activated Receptor (PPAR)-gamma Coactivator (PGC)-1 alpha gene rs8192678 polymorphism by gender on different health-related parameters in healthy young adults. Frontiers in Physiology, 1507.Tipo de Ítem:
Articulo Revista IndexadaResumen:
This study aimed to analyze the influence of the peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1 alpha (PPARGC1A) gene rs8192678 C > T polymorphism on different health-related parameters in male and female young adults. The PPARGC1A gene rs8192678 polymorphism was ascertained by polymerase chain reaction in 74 healthy adults (28 women; 22.72 +/- 4.40 years) from Andalusia (Spain). Health-related variables included cardiometabolic risk, anthropometry and body composition, biochemical parameters, insulin sensitivity (QUICKI and HOMA-IR indexes), blood pressure (BP) at rest and after exercise, diet, basal metabolism, physical activity, maximal fat oxidation, and cardiorespiratory fitness. Our results showed differences by PPARGC1A gene rs8192678 C > T polymorphism in body mass (p = 0.002), body mass index (p = 0.024), lean body mass (p = 0.024), body fat (p = 0.032), waist circumference (p = 0.020), and BP recovery ratio (p < 0.001). The recessive model (CC vs. CT/TT) showed similar results but also with differences in basal metabolism (p = 0.045) and total energy expenditure (p = 0.024). A genotype*sex interaction was found in the QUICKI index (p = 0.016), with differences between CC and CT/TT in men (p = 0.049) and between men and women inside the CT/TT group (p = 0.049). Thus, the PPARGC1A gene rs8192678 C > T polymorphism is associated with body composition, basal metabolism, total energy expenditure, and BP recovery, where the CC genotype confers a protective effect. Moreover, our study highlighted sexual dimorphism in the influence of PPARGC1A gene rs8192678 C > T polymorphism on the QUICKI index.
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