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dc.contributor.authorPacheco, Valeria B.
dc.contributor.authorNery, Giulia
dc.contributor.authorFernandes, Larissa L.
dc.contributor.authorSantana, Thais V.
dc.contributor.authorJimenez, Manuel
dc.contributor.authorBorges, Leandro
dc.contributor.authorHatanaka, Elaine
dc.contributor.authorBraga, Pedro
dc.contributor.authorMonteiro, Fernanda R.
dc.contributor.authorAmaral, Jônatas B.
dc.contributor.authorAlves, Luana S.
dc.contributor.authorBachi, André L. L.
dc.contributor.authorGomes Da Silva, Sérgio
dc.contributor.authorBirbrair, Alexander
dc.contributor.authorHeller, Debora
dc.date2022
dc.date.accessioned2022-12-07T11:26:21Z
dc.date.available2022-12-07T11:26:21Z
dc.identifier.citationPacheco, V. B., Nery, G., Fernandes, L. L., Santana, T. V., Jimenez, M., Borges, L., ... & Heller, D. (2022). Salivary Proteome, Inflammatory, and NETosis Biomarkers in Older Adult Practitioners and Nonpractitioners of Physical Exercise. Oxidative Medicine and Cellular Longevity, 2022.
dc.identifier.issn1942-0900
dc.identifier.urihttps://reunir.unir.net/handle/123456789/13870
dc.description.abstractSince aging has been associated with increased production of inflammatory biomarkers, the ability to monitor older adults repeatedly is highly desirable, and saliva is an interesting biofluid for the search of biomarkers, as it is easily accessible in a noninvasive manner. However, given the incipient knowledge of salivary biomarkers in aging and its relationship to physical exercise, the present study is aimed at evaluating the protein expression and the levels of inflammatory and NETosis biomarkers in the saliva of practitioners (PE) and nonpractitioners (NPE) of physical exercise older adults. Six (6) practitioner and 4 nonpractitioner older adults were enrolled in this study. Unstimulated whole saliva was collected for analysis of the proteome by label-free mass spectrometry, as well as of the inflammatory status by evaluation of C-reactive protein (CRP), vascular endothelial growth factor (VEGF), and cytokines (TNF-α, interleukin- (IL-) 1β, and IL-8), while NETosis was assessed by myeloperoxidase (MPO) and neutrophil elastase. Regarding oral health, the decayed, missing, and filled teeth (DMF-T) index, bleeding on probing, suppuration, and probing depth measurement (mm) were evaluated. In addition, functional capacity was investigated using the General Physical Fitness Index (GPFI). In relation to the proteome analysis, 93 and 143 proteins were found exclusively in the PE and NPE groups, respectively; 224 proteins were common to both groups. Among these proteins, 10 proteins showed statistical difference () between the groups: alpha-2-macroglobulin, component 3 of the complement, serotransferrin, and protein soluble in brain acid 1 were less expressed, while lactotransferrin, alpha-amylase 1, S100-A8, S100-A9, lactoperoxidase, and galectin-3 binding protein were more expressed in the PE group. No differences between groups were observed in the analysis of inflammatory and NETosis biomarkers. This study shows the potential utility of saliva for detecting protein biomarkers in a noninvasive biological sample of the elderly population.es_ES
dc.language.isoenges_ES
dc.publisherOxidative Medicine and Cellular Longevityes_ES
dc.relation.ispartofseries;vol. 2022, nº 3725056
dc.relation.urihttps://www.hindawi.com/journals/omcl/2022/3725056/es_ES
dc.rightsopenAccesses_ES
dc.subjectacidses_ES
dc.subjectaginges_ES
dc.subjectamylasees_ES
dc.subjectanalysises_ES
dc.subjectcapacityes_ES
dc.subjectevaluationes_ES
dc.subjecthealthes_ES
dc.subjectproteinses_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleSalivary Proteome, Inflammatory, and NETosis Biomarkers in Older Adult Practitioners and Nonpractitioners of Physical Exercisees_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1155/2022/3725056


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