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dc.contributor.authorThompson, Hayley A
dc.contributor.authorMousa, Andria
dc.contributor.authorDighe, Amy
dc.contributor.authorFu, Han
dc.contributor.authorArnedo-Pena, Alberto
dc.contributor.authorBarrett, Peter
dc.contributor.authorBellido-Blasco, Juan
dc.contributor.authorBi, Qifang
dc.contributor.authorCaputi, Antonio
dc.contributor.authorChaw, Liling
dc.contributor.authorDe Maria, Luigi
dc.contributor.authorHoffmann, Matthias
dc.contributor.authorMahapure, Kiran
dc.contributor.authorNg, Kangqi
dc.contributor.authorRaghuram, Jagadesan
dc.contributor.authorSingh, Gurpreet
dc.contributor.authorSoman, Biju
dc.contributor.authorValent, Francesca
dc.contributor.authorVimercati, Luigi
dc.contributor.authorWee, Liang En
dc.contributor.authorWong, Justin
dc.contributor.authorGhani, Azra C
dc.contributor.authorFerguson, Neil M.
dc.date2021
dc.date.accessioned2022-05-13T11:45:07Z
dc.date.available2022-05-13T11:45:07Z
dc.identifier.issn1058-4838
dc.identifier.urihttps://reunir.unir.net/handle/123456789/13100
dc.description.abstractBackground: Understanding the drivers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission is crucial for control policies, but evidence of transmission rates in different settings remains limited. Methods: We conducted a systematic review to estimate secondary attack rates (SARs) and observed reproduction numbers (Robs) in different settings exploring differences by age, symptom status, and duration of exposure. To account for additional study heterogeneity, we employed a beta-binomial model to pool SARs across studies and a negative-binomial model to estimate Robs. Results: Households showed the highest transmission rates, with a pooled SAR of 21.1% (95% confidence interval [CI]:17.4-24.8). SARs were significantly higher where the duration of household exposure exceeded 5 days compared with exposure of ≤5 days. SARs related to contacts at social events with family and friends were higher than those for low-risk casual contacts (5.9% vs 1.2%). Estimates of SARs and Robs for asymptomatic index cases were approximately one-seventh, and for presymptomatic two-thirds of those for symptomatic index cases. We found some evidence for reduced transmission potential both from and to individuals younger than 20 years of age in the household context, which is more limited when examining all settings. Conclusions: Our results suggest that exposure in settings with familiar contacts increases SARS-CoV-2 transmission potential. Additionally, the differences observed in transmissibility by index case symptom status and duration of exposure have important implications for control strategies, such as contact tracing, testing, and rapid isolation of cases. There were limited data to explore transmission patterns in workplaces, schools, and care homes, highlighting the need for further research in such settings.es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation.ispartofseries;vol. 73, nº 3
dc.relation.urihttps://academic.oup.com/cid/article/73/3/e754/6131730es_ES
dc.rightsopenAccesses_ES
dc.subjectcontact tracinges_ES
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectsecondary attack ratees_ES
dc.subjecttransmissiones_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleSevere Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Setting-specific Transmission Rates: A Systematic Review and Meta-analysises_ES
dc.typearticlees_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1093/cid/ciab100


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