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Influence of ace gene I/D polymorphism on cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet and physical activity in young adults
dc.contributor.author | Montes-De-oca-garcia, Adrián | |
dc.contributor.author | Perez-Bey, Alejandro | |
dc.contributor.author | Velazquez-Diaz, Daniel | |
dc.contributor.author | Corral-Perez, Juán | |
dc.contributor.author | Opazo-Diaz, Edgardo | |
dc.contributor.author | Rebollo-Ramos, María | |
dc.contributor.author | Gómez-Gallego, Felix | |
dc.contributor.author | Cuenca-Garcia, Magdalena | |
dc.contributor.author | Casals, Cristina | |
dc.contributor.author | Ponce-González, Jesús | |
dc.date | 2021 | |
dc.date.accessioned | 2021-07-22T10:30:45Z | |
dc.date.available | 2021-07-22T10:30:45Z | |
dc.identifier.issn | 1661-7827 | |
dc.identifier.uri | https://reunir.unir.net/handle/123456789/11644 | |
dc.description.abstract | There is controversy about the relationship between ACE I/D polymorphism and health. Seventy-four healthy adults (n = 28 women; 22.5 ± 4.2 years) participated in this cross-sectional study aimed at determining the influence of ACE I/D polymorphism, ascertained by polymerase chain reaction, on cardiometabolic risk (i.e., waist circumference, body fat, blood pressure (BP), glucose, triglycerides, and inflammatory markers), maximal fat oxidation (MFO), cardiorespira-tory fitness (maximal oxygen uptake), physical activity and diet. Our results showed differences by ACE I/D polymorphism in systolic BP (DD: 116.4 ± 11.8 mmHg; ID: 116.7 ± 6.3 mmHg; II: 109.4 ± 12.3 mmHg, p = 0.035) and body fat (DD: 27.3 ± 10.8%; ID: 22.6 ± 9.7%; II: 19.3 ± 7.1%, p = 0.030). Interestingly, a genotype*sex interaction in relativized MFO by lean mass (p = 0.048) was found. The DD polymorphism had higher MFO values than ID/II polymorphisms in men (8.4 ± 3.0 vs. 6.5 ± 2.9 mg/kg/min), while the ID/II polymorphisms showed higher R-MFO values than DD polymorphism in women (6.6 ± 2.3 vs. 7.6 ± 2.6 mg/kg/min). In conclusion, ACE I/D polymor-phism is apparently associated with adiposity and BP, where a protective effect can be attributed to the II genotype, but not with cardiorespiratory fitness, diet and physical activity. Moreover, our study highlighted that there is a sexual dimorphism in the influence of ACE I/D gene polymorphism on MFO. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | International journal of environmental research and public health | es_ES |
dc.relation.ispartofseries | ;vol. 18, nº 7 | |
dc.relation.uri | https://www.mdpi.com/1660-4601/18/7/3443 | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | angiotensin-converting enzyme | es_ES |
dc.subject | genetic association studies | es_ES |
dc.subject | healthy lifestyle | es_ES |
dc.subject | heart diseases | es_ES |
dc.subject | lipid metabolism | es_ES |
dc.subject | obesity | es_ES |
dc.subject | Scopus | es_ES |
dc.subject | WOS(2) | es_ES |
dc.title | Influence of ace gene I/D polymorphism on cardiometabolic risk, maximal fat oxidation, cardiorespiratory fitness, diet and physical activity in young adults | es_ES |
dc.type | Articulo Revista Indexada | es_ES |
reunir.tag | ~ARI | es_ES |
dc.identifier.doi | https://doi.org/10.3390/ijerph18073443 |
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