Down’s syndrome and COVID-19: risk or protection factor against infection? A molecular and genetic approach
Autor:
Altable, Marcos
; De la Serna Tuya, Juan Moisés (1)
Fecha:
2021Palabra clave:
Tipo de Ítem:
Articulo Revista Indexada
Resumen:
Down syndrome (DS) is the most common genetic cause of learning difficulties and intellectual disabilities. DS patients often present with several congenital defects and chronic diseases, including immunity disorders. Elevated levels of pro-inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α) have been seen, which appear to vary with age. At birth, patients present with combined immunodeficiency, with frequent infections that decrease with age. Furthermore, high levels of IL-4 and IL-10 with anti-inflammatory properties and low levels of IL-6 and TNF-α are described in children. The immune system is believed to play an essential role in SARS-CoV-2 pathogenesis, and it has been associated with elevated levels of pro-inflammatory cytokines and an exaggerated cytokine release syndrome (CRS) that may eventually trigger a severe situation called cytokine storm. On the other hand, genetic features seem to be involved in the predisposition to illness and its severity. Overexpression of DSCR1 and ZAKI-4 inhibits the translocation of activated T lymphocyte nuclear factor (NF-AT) to the nucleus, a main step in the inflammatory responsiveness. We discuss here the possible role of immunology and genetic features of DS in the infection and prognosis in COVID-19.
Este ítem aparece en la(s) siguiente(s) colección(es)
Estadísticas de uso
Año |
2012 |
2013 |
2014 |
2015 |
2016 |
2017 |
2018 |
2019 |
2020 |
2021 |
2022 |
Vistas |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
24 |
22 |
Descargas |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Ítems relacionados
Mostrando ítems relacionados por Título, autor o materia.
-
Neuropathogenesis in COVID-19
Altable, Marcos; De la Serna Tuya, Juan Moisés (1) (Journal of Neuropathology & Experimental Neurology, 11/2020)SARS-CoV-2 or COVID-19 is a new human coronavirus that emerged in Wuhan, China in late 2019 and is currently causing a pandemic (1, 2). With the possibility of future outbreaks of the disease, it may manifest with diverse ... -
Substance Use Disorders in ADHD: A Multimodal Approach
Altable, Marcos; De la Serna Tuya, Juan Moisés (1); Diaz, Emilio; Srifi Hasnaoui, Adnan (Annals of medical and heallth sciences research, 2021)Attention Deficit Hyperactivity Disorder (ADHD) is today one of the most relevant disorders in the clinical setting, not only because of its prevalence but also because of its high comorbidity with other diseases. Its ... -
Pathophysiology of Psychiatric Symptoms in COVID-19 and Biomarkers (IL-6, Platelets, Ferritin, Lymphopenia and Urea)
Altable, Marcos; De la Serna Tuya, Juan Moisés (1); Diaz, Emilio; Srifi Hasnaoui, Adnan (Annals of medical and heallth sciences research, 2021)Most of the studies on the COVID-19 pandemic produced by the SARS-CoV-2 reported neuropsychiatric symptoms only as part of the manifestations of the disease in its terminal phase. However, there are neuropsychiatric symptoms ...