• Mi Re-Unir
    Búsqueda Avanzada
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    Ver ítem 
    •   Inicio
    • RESULTADOS DE INVESTIGACIÓN
    • Artículos Científicos WOS y SCOPUS
    • Ver ítem
    •   Inicio
    • RESULTADOS DE INVESTIGACIÓN
    • Artículos Científicos WOS y SCOPUS
    • Ver ítem

    The Polemic Diagnostic Role of TP53 Mutations in Liquid Biopsies from Breast, Colon and Lung Cancers

    Autor: 
    Garrido-Navas, M. Carmen (1)
    ;
    García-Díaz, Abel
    ;
    Molina-Vallejo, María Pilar
    ;
    González-Martínez, Coral
    ;
    Alcaide Lucena, Miriam
    ;
    Cañas-García, Inés
    ;
    Bayarri, Clara
    ;
    Delgado, Juan Ramón
    ;
    González, Encarna
    ;
    Lorente, José Antonio
    ;
    Serrano, M. José
    Fecha: 
    11/2020
    Palabra clave: 
    TP53 mutations; liquid biopsy; cfDNA; CTC; tissue; concordance; JCR; Scopus
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/11158
    DOI: 
    https://doi.org/10.3390/cancers12113343
    Dirección web: 
    https://www.mdpi.com/2072-6694/12/11/3343
    Open Access
    Resumen:
    Being minimally invasive and thus allowing repeated measures over time, liquid biopsies are taking over traditional solid biopsies in certain circumstances such as those for unreachable tumors, very early stages or treatment monitoring. However, regarding TP53 mutation status analysis, liquid biopsies have not yet substituted tissue samples, mainly due to the lack of concordance between the two types of biopsies. This needs to be examined in a study-dependent manner, taking into account the particular type of liquid biopsy analyzed, that is, circulating tumor cells (CTCs) or cell-free DNA (cfDNA), its involvement in the tumor biology and evolution and, finally, the technology used to analyze each biopsy type. Here, we review the main studies analyzing TP53 mutations in either CTCs or cfDNA in the three more prevalent solid tumors: breast, colon and lung cancers. We evaluate the correlation for mutation status between liquid biopsies and tumor tissue, suggesting possible sources of discrepancies, as well as evaluating the clinical utility of using liquid biopsies for the analysis of TP53 mutation status and the future actions that need to be undertaken to make liquid biopsy analysis a reality for the evaluation of TP53 mutations.
    Descripción: 
    Most solid tumors share mutations in TP53 that is thus considered one of the main cancer driver genes. Mutations in TP53 occur very early during tumor development, so their identification helps in diagnosing cancer. Furthermore, knowing in advance the TP53 mutation status might help guiding targeted treatments against this gene. However, this analysis is mainly performed in tissue samples, that is, solid biopsies, being an invasive technique. Contrarily, liquid biopsies, consisting of the analysis of blood samples, are non-invasive, can be performed repeatedly, helping in monitoring the patient evolution, and might be useful in early stages when the tumor is not yet detected by other technologies. Here, we review the main studies conducted on two types of liquid biopsies: circulating tumor cells and cell-free DNA. We discuss the main findings regarding TP53 mutation analysis, the clinical utility of this information and some controversies arising from the study of liquid biopsies compared to tissue samples, and we finish by suggesting future directions within this field.
    Mostrar el registro completo del ítem
    Ficheros en el ítem
    icon
    Nombre: The Polemic Diagnostic.pdf
    Tamaño: 297.3Kb
    Formato: application/pdf
    Ver/Abrir
    Este ítem aparece en la(s) siguiente(s) colección(es)
    • Artículos Científicos WOS y SCOPUS

    Estadísticas de uso

    Año
    2012
    2013
    2014
    2015
    2016
    2017
    2018
    2019
    2020
    2021
    2022
    2023
    Vistas
    0
    0
    0
    0
    0
    0
    0
    0
    0
    53
    63
    1
    Descargas
    0
    0
    0
    0
    0
    0
    0
    0
    0
    26
    42
    0

    Ítems relacionados

    Mostrando ítems relacionados por Título, autor o materia.

    • Cross-Resistance to Abiraterone and Enzalutamide in Castration Resistance Prostate Cancer Cellular Models Is Mediated by AR Transcriptional Reactivation 

      Simon, Iris; Perales, Sonia; Casado-Medina, Laura; Rodríguez-Martínez, Alba; Garrido-Navas, M. Carmen (1); Puche-Sanz, Ignacio; Diaz-Mochon, Juan J.; Alaminos, Clara; Lupiañez, Pablo; Lorente, José Antonio; Serrano, M. José; Real, Pedro J. (Cancers, 2021)
      Androgen deprivation therapy (ADT) and novel hormonal agents (NHAs) (Abiraterone and Enzalutamide) are the goal standard for metastatic prostate cancer (PCa) treatment. Although ADT is initially effective, a subsequent ...
    • CYSAS-S3: a novel dataset for validating cyber situational awareness related tools for supporting military operations 

      Daton Medenou, Roumen (1); Calzado Mayo, Victor Manuel; Garcia Balufo, Miriam; Páramo Castrillo, Miguel; González Garrido, Francisco José; Luis Martinez, Alvaro; Nevado Catalán, David; Hu, Ao; Sandoval Rodríguez-Bermejo, David; Maestre Vidal, Jorge; Pasqual De Riquelme, Gerardo Ramis; Berardi, Antonio; De Santis, Paolo; Torelli, Francesco; Llopis Sanchez, Salvador (ACM International Conference Proceeding Series, 2020)
      The lack of suitable datasets and evaluation processes entails one of the most challenging gaps on the digital transformation era, where data-driven solutions like machine learning algorithms constitute a key pillar of the ...
    • A school-based physical activity promotion intervention in children: rationale and study protocol for the PREVIENE Project 

      Tercedor, Pablo; Villa-González, Emilio; Ávila-García, Manuel; Díaz-Piedra, Carolina; Martínez-Baena, Alejandro; Soriano-Maldonado, Alberto; Pérez-López, Isaac José; García-Rodríguez, Inmaculada; Mandic, Sandra; Palomares Cuadros, Juan (1); Segura-Jiménez, Victor; Huertas-Delgado, Francisco Javier (BMC Public Health, 09/2017)
      Background The lack of physical activity and increasing time spent in sedentary behaviours during childhood place importance on developing low cost, easy-toimplement school-based interventions to increase physical activity ...

    Mi cuenta

    AccederRegistrar

    ¿necesitas ayuda?

    Manual de UsuarioAutorización TFG-M

    Listar

    todo Re-UnirComunidades y coleccionesPor fecha de publicaciónAutoresTítulosPalabras claveTipo documentoTipo de accesoEsta colecciónPor fecha de publicaciónAutoresTítulosPalabras claveTipo documentoTipo de acceso






    Aviso Legal Política de Privacidad Política de Cookies Cláusulas legales RGPD
    © UNIR - Universidad Internacional de La Rioja
     
    Aviso Legal Política de Privacidad Política de Cookies Cláusulas legales RGPD
    © UNIR - Universidad Internacional de La Rioja