Listar por tema "Leishmania"

Mostrando ítems 1-2 de 2

A yeast-based high-throughput screen identifies inhibitors of trypanosomatid HRG heme transporters with potent leishmanicidal and trypanocidal activity

Cabello-Donayre, María; Cabello-Donayre, Irene; Guerra, Diego; Orrego, Lina M.; Morales, Juan C.; Cautain, Bastien; Vicente, Francisca; Pérez-Victoria, José M. (International Journal of Antimicrobial Agents, 2024)

Objectives: New drugs are required to treat neglected diseases caused by trypanosomatid parasites such as Leishmania, Trypanosoma brucei and Trypanosoma cruzi . An Achilles’ heel of these parasites is their heme auxotrophy; ...
FiCRoN, a deep learning-based algorithm for the automatic determination of intracellular parasite burden from fluorescence microscopy images

Juez-Castillo, Graciela; Valencia-Vidal, Brayan; Orrego, Lina M.; Cabello-Donayre, María; Montosa-Hidalgo, Laura; Pérez-Victoria, José M. (Medical Image Analysis, 2024)

Protozoan parasites are responsible for dramatic, neglected diseases. The automatic determination of intracellular parasite burden from fluorescence microscopy images is a challenging problem. Recent advances in deep ...