Mostrando ítems 11-20 de 53
Gene editing for HIV cure at the edge
(AIDS Reviews, 2019-01)
Whereas advances in antiretroviral therapy and its widespread use are providing huge benefits in terms of prventing new HIV transmissions to uninfected individuals as well as halting disease progression in patients, the ...
Jerome Lejeune passed away 25 years ago
During the past 60 years, modern genetics has steadily evolved from diagnostics to therapeutics. However, treatment of genetic disorders is still in its infancy, with the advent of genome editing as its greatest promise.
Clinical Presentation of Individuals With Human T-Cell Leukemia Virus Type-1 Infection in Spain
(Open Forum Infectious Diseases, 2019-02)
Background. Although only 8%-10% of persons infected with human T-cell leukemia virus type 1 (HTLV-1) may develop virus-associated diseases lifelong, misdiagnosis of asymptomatic infected carriers frequently leads to late ...
Predictors of Hepatitis C Treatment Failure After Using Direct-Acting Antivirals in People Living With Human Immunodeficiency Virus
(Open Forum Infectious Diseases, 2019-03)
Background. Little is known about the influence of ongoing barriers to care in the persistence of hepatitis C virus (HCV) viremia after treatment with direct-acting antivirals (DAAs) among people living with human ...
HIV co-infection in HTLV-1 carriers in Spain
(Virus Research, 2019-06)
Background: Human retroviruses HIV and HTLV share transmission routes. HIV widely spread in Spain during the 80 s through injection drug use and sex, and nowadays HIV rates in Spain account for one of the largest in Europe. ...
Update of the statements on biology and clinical impact of occult hepatitis B virus infection
(Journal of Hepatology, 2019-08)
In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were ...
HTLV-1 infection in solid organ transplant donors and recipients in Spain
(BMC Invectious Diseases, 2019-08-09)
Background: HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated ...
Clinical experience with integrase inhibitors in HIV-2-infected individuals in Spain
(Journal of Antimicrobial Chemotherapy, 2019-05)
Background: HIV-2 is a neglected virus despite estimates of 1-2 million people being infected worldwide. The virus is naturally resistant to some antiretrovirals used to treat HIV-1 and therapeutic options are limited for ...
Why Not an Opioid Epidemic in Europe Like in the USA?
(AIDS Reviews, 2019-12)
The CDC reported 70,237 drug overdose deaths in the United States in 2017 (Scholl et al., MMWR 2018; 67: 1419-27). Sadly, this yearly rate has been increasing significantly during the past two decades. Opioids, mostly ...
Treatment outcome in dually HIV-1 and HIV-2 coinfected patients living in Spain
Background: Whereas HIV-1 has spread globally, HIV-2 is mainly found in West Africa where dual HIV-1/HIV-2 coinfection is nowadays uncommon. Herein, we report the rate, main characteristics, and treatment outcomes of all ...