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Listar Artículos Científicos WOS y SCOPUS por autor "Salcines-Cuevas, David"
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A Comparison Between Recombinant Listeria GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for Listeria, Mycobacterium, and Streptococcus
Teran-Navarro, Héctor; Salcines-Cuevas, David; Calderón-González, Ricardo; Tobes, Raquel; Calvo-Montes, Jorge; Pérez-Del Molino Bernal, Inmaculada Concepción; Yañez-Diaz, Sonsoles; Fresno, Manuel; Álvarez-Domínguez, Carmen (Frontiers in immunology, 2021)Cross-reactive vaccines recognize common molecular patterns in pathogens and are able to confer broad spectrum protection against different infections. Antigens common to pathogenic bacteria that induce broad immune ... -
Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase
Álvarez-Domínguez, Carmen ; Salcines-Cuevas, David; Teran-Navarro, Héctor; Calderón-González, Ricardo; Tobes, Raquel; García, Isabel; Grijalvo, Santiago; Paradela, Alberto; Seoane, Asunción; Sangari, Felix J.; Fresno, Manuel; Calvo-Montes, Jorge; Pérez Del Molino Bernal, I. Concepción; Yañez-Diaz, Sonsoles (Frontiers in Cellular and Infection Microbiology, 10/2020)The glycolytic enzyme and bacterial virulence factor of Listeria monocytogenes, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Lmo2459), ADP-ribosylated the small GTPase, Rab5a, and blocked phagosome maturation. This ... -
First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine
Martinez, Luis; Malaina, Iker; Salcines-Cuevas, David; Teran-Navarro, Héctor; Zeoli, Andrea; Alonso, Santos; De la Fuente, Ildefonso M.; Gonzalez-Lopez, Elena; Ocejo-Vinyals, J. Gonzalo; Gozalo-Marguello, Monica; Calvo-Montes, Jorge; Álvarez-Domínguez, Carmen (Scientific reports, 2022)Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the present time, and considerable public and private effort is being devoted to fighting this recently emerged disease. Despite the undoubted ... -
Glyceraldehyde-3-phosphate dehydrogenase common peptides of listeria monocytogenes, mycobacterium marinum and streptococcus pneumoniae as universal vaccines
Salcines-Cuevas, David; Teran-Navarro, Héctor; Calderón-González, Ricardo; Torres-Rodriguez, Paula; Tobes, Raquel; Fresno, Manuel; Calvo-Montes, Jorge; Pérez Del Molino-Bernal, Concepción; Yañez-Diaz, Sonsoles; Álvarez-Domínguez, Carmen (Vaccines, 2021)Universal vaccines can be prepared with antigens common to different pathogens. In this regard, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a common virulence factor among pathogenic bacteria of the genera ... -
Testing a vaccine candidate against Hepatitis C virus designed by combinatorial optimization
Malaina, Iker; Martinez, Luis; Salcines-Cuevas, David; Teran-Navarro, Héctor; Ocejo-Vinyals, J. Gonzalo; Gonzalez-Lopez, Elena; Soriano, Vicente; Úbeda Cantera, María; Pérez Pinilla, Martin-Blas; Martínez de la Fuente, Ildefonso; Álvarez-Domínguez, Carmen (Scientific Reports, 2023)This paper presents a new procedure for vaccine design against highly variable viruses such as Hepatitis C. The procedure uses an optimization algorithm to design vaccines that maximize the coverage of epitopes across ...