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Listar RESULTADOS DE INVESTIGACIÓN por autor "Álvarez-Domínguez, Carmen"
Mostrando ítems 1-9 de 9
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A Comparison Between Recombinant Listeria GAPDH Proteins and GAPDH Encoding mRNA Conjugated to Lipids as Cross-Reactive Vaccines for Listeria, Mycobacterium, and Streptococcus
Teran-Navarro, Héctor; Salcines-Cuevas, David; Calderón-González, Ricardo; Tobes, Raquel; Calvo-Montes, Jorge; Pérez-Del Molino Bernal, Inmaculada Concepción; Yañez-Diaz, Sonsoles; Fresno, Manuel; Álvarez-Domínguez, Carmen (Frontiers in immunology, 2021)Cross-reactive vaccines recognize common molecular patterns in pathogens and are able to confer broad spectrum protection against different infections. Antigens common to pathogenic bacteria that induce broad immune ... -
Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase
Álvarez-Domínguez, Carmen ; Salcines-Cuevas, David; Teran-Navarro, Héctor; Calderón-González, Ricardo; Tobes, Raquel; García, Isabel; Grijalvo, Santiago; Paradela, Alberto; Seoane, Asunción; Sangari, Felix J.; Fresno, Manuel; Calvo-Montes, Jorge; Pérez Del Molino Bernal, I. Concepción; Yañez-Diaz, Sonsoles (Frontiers in Cellular and Infection Microbiology, 10/2020)The glycolytic enzyme and bacterial virulence factor of Listeria monocytogenes, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH, Lmo2459), ADP-ribosylated the small GTPase, Rab5a, and blocked phagosome maturation. This ... -
First computational design using lambda-superstrings and in vivo validation of SARS-CoV-2 vaccine
Martinez, Luis; Malaina, Iker; Salcines-Cuevas, David; Teran-Navarro, Héctor; Zeoli, Andrea; Alonso, Santos; De la Fuente, Ildefonso M.; Gonzalez-Lopez, Elena; Ocejo-Vinyals, J. Gonzalo; Gozalo-Marguello, Monica; Calvo-Montes, Jorge; Álvarez-Domínguez, Carmen (Scientific reports, 2022)Coronavirus disease 2019 (COVID-19) is the greatest threat to global health at the present time, and considerable public and private effort is being devoted to fighting this recently emerged disease. Despite the undoubted ... -
Glyceraldehyde-3-phosphate dehydrogenase common peptides of listeria monocytogenes, mycobacterium marinum and streptococcus pneumoniae as universal vaccines
Salcines-Cuevas, David; Teran-Navarro, Héctor; Calderón-González, Ricardo; Torres-Rodriguez, Paula; Tobes, Raquel; Fresno, Manuel; Calvo-Montes, Jorge; Pérez Del Molino-Bernal, Concepción; Yañez-Diaz, Sonsoles; Álvarez-Domínguez, Carmen (Vaccines, 2021)Universal vaccines can be prepared with antigens common to different pathogens. In this regard, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a common virulence factor among pathogenic bacteria of the genera ... -
Gold Glyconanoparticles Combined with 91–99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors
Terán-Navarro, Hector; Zeoli, Andrea; Salines-Cuevas, David; Marradi, Marco; Montoya, Noemí ; Gonzalez-Lopez, Elena; Ocejo-Vinyals, J. Gonzalo; Dominguez-Esteban, Mario; Gutierrez-Baños, Jose Luis; Campos-Juanatey, Felix; Yañez-Diaz, Sonsoles; Garcia-Castaño, Almudena; Rivera, Fernando; Duran, Ignacio; Álvarez-Domínguez, Carmen (Cancers, 2022)This study presents proof of concept assays to validate gold nanoparticles loaded with the bacterial peptide 91–99 of the listeriolysin O toxin (GNP-LLO91–99 nanovaccines) as immunotherapy for bladder tumors. GNP-LLO91–99 ... -
Online teaching methodology for adaptation to the new COVID19 pandemic situation in the master’s degree in teacher training at the Francisco de Vitoria University
Criado Martín, Antonio J. ; Criado Martín, Alejandro; Lanagrán Valero, Eva María ; Álvarez-Domínguez, Carmen ; Nestares, Eva María ; Pérez Largacha, Antonio (CEUR workshop proceedings, 2021)This paper develops the teaching method that is carried out in the subjects of Curricular Development and Didactics of Geography and History, within the University Master’s Degree in Teacher Training for Compulsory Secondary ... -
Online teaching methodology in the speciality of sanitary area of the master’s degree in teacher training at UNIR, the University on the Internet.
Criado Martín, Antonio J. ; Criado Martín, Alejandro; Lanagrán Valero, Eva María ; Álvarez-Domínguez, Carmen ; Nestares, Eva María ; Pérez Largacha, Antonio (CEUR workshop proceedings, 2021)This paper develops the teaching method that is carried out in the subject of Complements for disciplinary training of health area, belonging to the speciality of health area, in the University Master’s Degree in Teacher ... -
Pirin is a prognostic marker of human melanoma that dampens the proliferation of malignant cells by downregulating JARID1B/KDM5B expression
Penas, Cristina; Arroyo-Berdugo, Yoana; Apraiz, Aintzane; Rasero, Javier; Muñoa-Hoyos, Iraia; Andollo, Noelia; Cancho-Galán, Goikoane; Izu, Rosa; Gardeazabal, Jesús; Ezkurra, Pilar A.; Subiran, Nerea; Álvarez-Domínguez, Carmen; Alonso, Santos; Bosserhoff, Anja K.; Asumendi, Aintzane; Boyano, María D. (Scientific Reports, 2023)Originally considered to act as a transcriptional co-factor, Pirin has recently been reported to play a role in tumorigenesis and the malignant progression of many tumors. Here, we have analyzed the diagnostic and prognostic ... -
Testing a vaccine candidate against Hepatitis C virus designed by combinatorial optimization
Malaina, Iker; Martinez, Luis; Salcines-Cuevas, David; Teran-Navarro, Héctor; Ocejo-Vinyals, J. Gonzalo; Gonzalez-Lopez, Elena; Soriano, Vicente; Úbeda Cantera, María; Pérez Pinilla, Martin-Blas; Martínez de la Fuente, Ildefonso; Álvarez-Domínguez, Carmen (Scientific Reports, 2023)This paper presents a new procedure for vaccine design against highly variable viruses such as Hepatitis C. The procedure uses an optimization algorithm to design vaccines that maximize the coverage of epitopes across ...