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dc.contributor.authorCorpas, Manuel
dc.contributor.authorde Mendoza, Carmen
dc.contributor.authorMoreno-Torres, Víctor
dc.contributor.authorPintos, Ilduara
dc.contributor.authorSeoane, Pablo
dc.contributor.authorPerkins, James R.
dc.contributor.authorRanea, Juan A.G.
dc.contributor.authorFatumo, Segun
dc.contributor.authorKorcsmaros, Tamas
dc.contributor.authorMartín-Villa, José Manuel
dc.contributor.authorBarreiro, Pablo
dc.contributor.authorCorral, Octavio Jorge
dc.date2023
dc.date.accessioned2023-10-23T11:37:11Z
dc.date.available2023-10-23T11:37:11Z
dc.identifier.citationCorpas, M., de Mendoza, C., Moreno-Torres, V., Pintos, I., Seoane, P., Perkins, J. R., ... & Soriano, V. (2023). Genetic signature detected in T cell receptors from patients with severe COVID-19. Iscience, 26(10).es_ES
dc.identifier.issn2589-0042
dc.identifier.urihttps://reunir.unir.net/handle/123456789/15442
dc.description.abstractCharacterization of host genetic factors contributing to COVID-19 severity promises advances on drug discovery to fight the disease. Most genetic analyses to date have identified genome-wide significant associations involving loss-of-function variants for immune response pathways. Despite accumulating evidence supporting a role for T cells in COVID-19 severity, no definitive genetic markers have been found to support an involvement of T cell responses. We analyzed 205 whole exomes from both a well-characterized cohort of hospitalized severe COVID-19 patients and controls. Significantly enriched high impact alleles were found for 25 variants within the T cell receptor beta (TRB) locus on chromosome 7. Although most of these alleles were found in heterozygosis, at least three or more in TRBV6-5, TRBV7-3, TRBV7-6, TRBV7-7, and TRBV10-1 suggested a possible TRB loss of function via compound heterozygosis. This loss-of-function in TRB genes supports suboptimal or dysfunctional T cell responses as a major contributor to severe COVID-19 pathogenesis.es_ES
dc.language.isoenges_ES
dc.publisheriSciencees_ES
dc.relation.ispartofseries;vol. 26, nº 10
dc.relation.urihttps://www.cell.com/iscience/fulltext/S2589-0042(23)01812-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223018126%3Fshowall%3Dtruees_ES
dc.rightsopenAccesses_ES
dc.subjectgeneticses_ES
dc.subjectgenomicses_ES
dc.subjectimmunologyes_ES
dc.subjectvirologyes_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.subjectWOSes_ES
dc.titleGenetic signature detected in T cell receptors from patients with severe COVID-19es_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1016/j.isci.2023.107735


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