Mostrar el registro sencillo del ítem

dc.contributor.authorArranz-Herrero, Javier
dc.contributor.authorPresa, Jesús
dc.contributor.authorRius-Rocabert, Sergio
dc.contributor.authorUtrero-Rico, Alberto
dc.contributor.authorArranz-Arija, José Ángel
dc.contributor.authorLalueza, Antonio
dc.contributor.authorEscribese, María M
dc.contributor.authorOchando, Jordi
dc.contributor.authorSoriano, Vicente
dc.contributor.authorNistal-Villan, Estanislao
dc.date2023
dc.date.accessioned2023-06-26T15:22:48Z
dc.date.available2023-06-26T15:22:48Z
dc.identifier.citationArranz-Herrero, J., Presa, J., Rius-Rocabert, S., Utrero-Rico, A., Arranz-Arija, J. Á., Lalueza, A., ... & Nistal-Villan, E. (2023). Determinants of poor clinical outcome in patients with influenza pneumonia: A systematic review and meta-analysis. International Journal of Infectious Diseases.es_ES
dc.identifier.issn1201-9712
dc.identifier.urihttps://reunir.unir.net/handle/123456789/14967
dc.description.abstractBackground: The clinical burden of influenza is increasing worldwide. Aging, immunosuppression, and underlying respiratory illness are determinants of poor clinical outcomes, including greater mortality. Bacterial infections seem to be the main reason. Updated information on the role of bacterial infection as the cause of complications would be of value in improving the prognosis of patients with influenza. Methods: A systematic review and meta-analysis were performed by using the PubMed repository using keywords like: Influenza, H1N1, Streptococcus pneumoniae, bacterial coinfection, secondary coinfection, bacterial complications in pneumonia, and seasonal influenza. Only articles written in English were included in publications from 2010 to 2020. The analyses were conducted following the preferred reporting items for systematic review and meta-analyses guidelines. The results were independently validated using a TrinetX database cohort of roughly 4 million patients. Results: We included 135 studies that contained data from 48,259 patients hospitalized with influenza of any age. Bacterial infections were diagnosed in 5391 (11.2%). Streptococcus pneumoniae (30.7%) and Staphylococcus aureus (30.4%) were the most frequent microorganisms, followed by Haemophilus influenzae (7.1%) and Pseudomonas aeruginosa (5.9%). The random-effects model of the meta-analysis indicated that bacterial infections posed a 3.4-fold increased risk of death compared with influenza infection alone. Unexpectedly, asthma was protective (odds ratio 0.8). Conclusion: Bacterial infections diagnosed in 11.2% of patients with influenza increase 3.4-fold the mortality risk. S. pneumoniae, S. aureus, H. influenzae, and P. aeruginosa account for nearly 75% of the cases. Earlier diagnosis and use of antibiotics should improve outcomes in this population.es_ES
dc.language.isoenges_ES
dc.publisherInternational Journal of Infectious Diseaseses_ES
dc.relation.ispartofseries;vol. 131
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1201971223001352?via%3Dihubes_ES
dc.rightsopenAccesses_ES
dc.subjectantibiotic usees_ES
dc.subjectbacterial infectiones_ES
dc.subjectinfluenzaes_ES
dc.subjectprognosises_ES
dc.subjectstaphylococcus aureuses_ES
dc.subjectstreptococcus pneumoniaees_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleDeterminants of poor clinical outcome in patients with influenza pneumonia: A systematic review and meta-analysises_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2023.04.003


Ficheros en el ítem

Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem