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dc.contributor.authorFerraro, Laura
dc.contributor.authorLa Cascia, Caterina
dc.contributor.authorLa Barbera, Daniele
dc.contributor.authorSánchez-Gutiérrez, Teresa (1)
dc.contributor.authorTripoli, Giada
dc.contributor.authorSeminerio, Fabio
dc.contributor.authorSartorio, Crocettarachele
dc.contributor.authorSideli, Lucia
dc.contributor.authorArango, Celso
dc.contributor.authorArrojo, Manuel
dc.contributor.authorBernardo, Miguel
dc.contributor.authorBobes, Julio
dc.contributor.authorDel-Ben, Cristina Marta
dc.contributor.authorGayer-Anderson, Charlotte
dc.contributor.authorJongsma, Hannah E.
dc.contributor.authorKirkbride, James B.
dc.contributor.authorLasalvia, Antonio
dc.contributor.authorTosato, Sarah
dc.contributor.authorLlorca, Pierre-Michel
dc.contributor.authorMenezes, Paulo Rossi
dc.contributor.authorRutten, Bart P.
dc.contributor.authorSantos, Jose Luis
dc.contributor.authorSanjuán, Julio
dc.contributor.authorSelten, Jean-Paul
dc.contributor.authorSzöke, Andrei
dc.contributor.authorTarricone, Ilaria
dc.contributor.authorMuratori, Roberto
dc.contributor.authorTortelli, Andrea
dc.contributor.authorVelthorst, Eva
dc.contributor.authorRodriguez, Victoria
dc.contributor.authorQuattrone, Andrea
dc.contributor.authorJones, Peter B.
dc.contributor.authorVan Os, Jim
dc.contributor.authorVassos, Evangelos
dc.contributor.authorMorgan, Craig
dc.contributor.authorde Haan, Lieuwe
dc.contributor.authorReininghaus, Ulrich
dc.contributor.authorCardno, Alastair G.
dc.contributor.authorDi Forti, Marta
dc.contributor.authorMurray, Robin M.
dc.contributor.authorQuattrone, Diego
dc.description.abstractPremorbid functioning and cognitive measures may reflect gradients of developmental impairment across diagnostic categories in psychosis. In this study, we sought to examine the associations of current cognition and premorbid adjustment with symptom dimensions in a large first episode psychosis (FEP) sample. We used data from the international EU-GEI study. Bifactor modelling of the Operational Criteria in Studies of Psychotic Illness (OPCRIT) ratings provided general and specific symptom dimension scores. Premorbid Adjustment Scale estimated premorbid social (PSF) and academic adjustment (PAF), and WAIS-brief version measured IQ. A MANCOVA model examined the relationship between symptom dimensions and PSF, PAF, and IQ, having age, sex, country, self-ascribed ethnicity and frequency of cannabis use as confounders. In 785 patients, better PSF was associated with fewer negative (B = −0.12, 95% C.I. −0.18, −0.06, p < 0.001) and depressive (B = −0.09, 95% C.I. −0.15, −0.03, p = 0.032), and more manic (B = 0.07, 95% C.I. 0.01, 0.14, p = 0.023) symptoms. Patients with a lower IQ presented with slightly more negative and positive, and fewer manic, symptoms. Secondary analysis on IQ subdomains revealed associations between better perceptual reasoning and fewer negative (B = −0.09, 95% C.I. −0.17, −0.01, p = 0.023) and more manic (B = 0.10, 95% C.I. 0.02, 0.18, p = 0.014) symptoms. Fewer positive symptoms were associated with better processing speed (B = −0.12, 95% C.I. −0.02, −0.004, p = 0.003) and working memory (B = −0.10, 95% C.I. −0.18, −0.01, p = 0.024). These findings suggest that the negative and manic symptom dimensions may serve as clinical proxies of different neurodevelopmental predisposition in psychosis.es_ES
dc.publisherElsevier B.V.es_ES
dc.relation.ispartofseries;vol. 236
dc.subjectcognitive domainses_ES
dc.subjectfirst episode psychosises_ES
dc.subjectpremorbid adjustmentes_ES
dc.subjectsymptom dimensionses_ES
dc.titleThe relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI studyes_ES

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