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dc.contributor.authorMartínez-García, Laura
dc.contributor.authorEspinel, Marco Antonio
dc.contributor.authorAbreu, Melanie
dc.contributor.authorGonzález-Alba, José María
dc.contributor.authorGijón, Desirèe
dc.contributor.authorMcGee-Laso, Amaranta
dc.contributor.authorCantón, Rafael
dc.contributor.authorGalán, Juan Carlos
dc.contributor.authorAranaz Andrés, Jesús María (1)
dc.date2021
dc.date.accessioned2022-04-28T09:43:52Z
dc.date.available2022-04-28T09:43:52Z
dc.identifier.issn2076-2607
dc.identifier.urihttps://reunir.unir.net/handle/123456789/12967
dc.description.abstractIn December 2020, UK authorities warned of the rapid spread of a new SARS-CoV-2 var-iant, belonging to the B.1.1.7 lineage, known as the Alpha variant. This variant is characterized by 17 mutations and 3 deletions. The deletion 69–70 in the spike protein can be detected by commercial platforms, allowing its real-time spread to be known. From the last days of December 2020 and over 4 months, all respiratory samples with a positive result for SARS-CoV-2 from patients treated in primary care and the emergency department were screened to detect this variant based on the strategy S gene target failure (SGTF). The first cases were detected during week 53 (2020) and reached >90% of all cases during weeks 15–16 (2021). During this period, the B.1.1.7/SGTF variant spread at a rapid and constant replacement rate of around 30–36%. The probability of intensive care unit ad-mission was twice higher among patients infected by the B.1.1.7/SGTF variant, but there were no differences in death rate. During the peak of the third pandemic wave, this variant was not the most prevalent, and it became dominant when this wave was declining. Our results confirm that the B.1.1.7/SGTF variant displaced other SARS-CoV-2 variants in our healthcare area in 4 months. This displacement has led to an increase in the burden of disease.es_ES
dc.language.isoenges_ES
dc.publisherMDPI AGes_ES
dc.relation.ispartofseries;vol. 9, nº 7
dc.relation.urihttps://www.mdpi.com/2076-2607/9/7/1517es_ES
dc.rightsopenAccesses_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectB1.1.7 lineagees_ES
dc.subjectvariantses_ES
dc.subjectreplacementes_ES
dc.subjectburden of diseasees_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleEmergence and spread of b.1.1.7 lineage in primary care and clinical impact in the morbi-mortality among hospitalized patients in madrid, spaines_ES
dc.typearticlees_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.3390/microorganisms9071517


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