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dc.contributor.authorAleo, Esther
dc.contributor.authorLópez Picado, Amanda (1)
dc.contributor.authorJoyanes Abancens, Belén
dc.contributor.authorSoto Beauregard, Carmen
dc.contributor.authorTur Salamanca, Nuria
dc.contributor.authorEsteban Polonios, Carmen
dc.contributor.authorTorrejón, María José
dc.contributor.authorGonzález Perrino, Carlos
dc.contributor.authorRivas, Ana
dc.contributor.authorArias, Eva
dc.contributor.authorRodríguez, Diamelis
dc.contributor.authorRivas, Mª. Ángeles
dc.contributor.authorRodríguez Rojo, Marina Laura
dc.contributor.authorFernández García, Patricia
dc.contributor.authorRodríguez Alarcón, Jaime
dc.contributor.authorSan Pedro de Urquiza, Borja
dc.date2021
dc.date.accessioned2022-04-04T11:26:03Z
dc.date.available2022-04-04T11:26:03Z
dc.identifier.issn2314-6133
dc.identifier.urihttps://reunir.unir.net/handle/123456789/12796
dc.description.abstractSurgical procedures can generate significant preoperative anxiety (POA) in as much as 70% of the paediatric population. The role of hydroxyzine and distractive techniques such as clowns in the management of anxiety is controversial. Our main objective was to evaluate the effect of hydroxyzine on the control of POA. The secondary objective was to assess the potential additive effect of hydroxyzine and distracting techniques. We performed a randomized double-blind, controlled clinical trial in children aged 2-16 years undergoing outpatient surgery (n=165). Subjects were randomized to hydroxyzine (group 1) or placebo (group 2). For the secondary objective, two further groups were made by allocation by chance to hydroxyzine plus accompaniment with clowns (group 3) and placebo plus clowns (group 4). All patients were accompanied by their parents as the standard procedure. POA was determined by a modified Yale scale of POA (m-YPAS). Compliance of children during induction of anesthesia (Induction Compliance Checklist (ICC)) was also assessed. No differences (p=0.788) were found in POA control at the time of induction measured by m-YPAS (group 1: 39.2±27.9; group 2: 37.0±26.1; group 3: 34.7±25.5; group 4: 32.4±20.5). No differences were found in the level of ICC between the different treatment arms (group 1: 1.8±3.4; group 2: 1.5±3.0; group 3: 1.2±2.4; group 4: 1.5±2.7). The combination of all treatments (group 3) was the only effective strategy to contain the progression of anxiety. In conclusion, hydroxyzine was not effective to control POA in children. The combination of hydroxyzine and clowns avoided the progression of POA in our patients. This trial is registered with ClinicalTrials.gov identifier: NCT03324828 (registered 21 September 2017, subject recruitment started on 12th January 2018).es_ES
dc.language.isoenges_ES
dc.publisherHindawi Limitedes_ES
dc.relation.ispartofseries;vol. 2021
dc.relation.urihttps://www.hindawi.com/journals/bmri/2021/7394042/es_ES
dc.rightsopenAccesses_ES
dc.subjectadolescentses_ES
dc.subjectanesthesiaes_ES
dc.subjectanxietyes_ES
dc.subjectchildes_ES
dc.subjectchild, preschooles_ES
dc.subjectdouble-blind methodes_ES
dc.subjectfemalees_ES
dc.subjecthumanses_ES
dc.subjecthydroxyzinees_ES
dc.subjectmalees_ES
dc.subjectpreoperative carees_ES
dc.subjectpreoperative periodes_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleEvaluation of the Effect of Hydroxyzine on Preoperative Anxiety and Anesthetic Adequacy in Children: Double Blind Randomized Clinical Triales_ES
dc.typearticlees_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1155/2021/7394042


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