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dc.contributor.authorGriffin, Daniel O.
dc.contributor.authorBrennan-Rieder, Denise
dc.contributor.authorNgo, Binh
dc.contributor.authorKory, Pierre
dc.contributor.authorConfalonieri, Marco
dc.contributor.authorShapiro, Leland
dc.contributor.authorIglesias, Jose
dc.contributor.authorDube, Michael
dc.contributor.authorNanda, Neha
dc.contributor.authorIn, Gino K.
dc.contributor.authorArkfeld, Daniel
dc.contributor.authorChaudhary, Preet
dc.contributor.authorCampese, Vito M.
dc.contributor.authorHanna, Diana L.
dc.contributor.authorSawcer, David
dc.contributor.authorEhresmann, Glenn
dc.contributor.authorPeng, David
dc.contributor.authorSmorgorzewski, Miroslaw
dc.contributor.authorAmstrong, April
dc.contributor.authorVinjevoll, Eivind H.
dc.contributor.authorDasgupta, Rajkumar
dc.contributor.authorSattler, Fred R.
dc.contributor.authorMussini, Cristina
dc.contributor.authorMitjà, Oriol
dc.contributor.authorSoriano, Vicente
dc.contributor.authorPeschanski, Nicolas
dc.contributor.authorHayem, Gilles
dc.contributor.authorPiccirillo, Maria Carmela
dc.contributor.authorLobo-Ferreira, António
dc.contributor.authorB. Rivero, Iraldo
dc.contributor.authorHung, Ivan F. H.
dc.contributor.authorRendell, Marc
dc.contributor.authorDitmore, Stephen
dc.contributor.authorVaron, Joseph
dc.contributor.authorMarik, Paul
dc.date2021
dc.date.accessioned2021-07-09T09:14:32Z
dc.date.available2021-07-09T09:14:32Z
dc.identifier.issn16986997
dc.identifier.urihttps://reunir.unir.net/handle/123456789/11583
dc.description.abstractCOVID-19, caused by SARS-CoV-2, continues to be a major health problem since its first description in Wuhan, China, in December 2019. Multiple drugs have been tried to date in the treatment of COVID-19. Critical to treatment of COVID-19 and advancing therapeutics is an appreciation of the multiple stages of this disease and the importance of timing for investigation and use of various agents. We considered articles related to COVID-19 indexed on PubMed published January 1, 2020-November 15, 2020, and considered papers on the medRxiv preprint server. We identified relevant stages of COVID-19 including three periods: pre-exposure, incubation, and detectable viral replication; and five phases: the viral symptom phase, the early inflammatory phase, the secondary infection phase, the multisystem inflammatory phase, and the tail phase. This common terminology should serve as a framework to guide when COVID-19 therapeutics being studied or currently in use is likely to provide benefit rather than harm.es_ES
dc.language.isoenges_ES
dc.publisherAIDS reviewses_ES
dc.relation.ispartofseries;vol. 23, nº 1
dc.relation.urihttps://www.aidsreviews.com/resumen.php?id=1567es_ES
dc.rightsopenAccesses_ES
dc.subjectCOVID-19es_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectphaseses_ES
dc.subjectcytokine stormes_ES
dc.subjectantiviralses_ES
dc.subjectimmunotherapyes_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleThe Importance of Understanding the Stages of COVID-19 in Treatment and Trialses_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.24875/AIDSRev.200001261


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