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dc.contributor.authorMurueta-Goyena, Ane
dc.contributor.authorPino, Rocío Del (1)
dc.contributor.authorGaldós, Marta
dc.contributor.authorArana, Begoña
dc.contributor.authorAcera, Marian
dc.contributor.authorCarmona‐Abellán, Mar
dc.contributor.authorFernández‐Valle, Tamara
dc.contributor.authorTijero, Beatriz
dc.contributor.authorLucas‐Jiménez, Olaia
dc.contributor.authorOjeda, Natalia
dc.contributor.authorIbarretxe‐Bilbao, Naroa
dc.contributor.authorPeña, Javier
dc.contributor.authorCortés, Jesús
dc.contributor.authorAyala, Unai
dc.contributor.authorBarrenechea, Maitane
dc.contributor.authorGómez‐Esteban, Juan Carlos
dc.contributor.authorGabilondo, Iñigo
dc.description.abstractObjective This study was undertaken to analyze longitudinal changes of retinal thickness and their predictive value as biomarkers of disease progression in idiopathic Parkinson's disease (iPD). Methods Patients with Lewy body diseases were enrolled and prospectively evaluated at 3 years, including patients with iPD (n = 42), dementia with Lewy bodies (n = 4), E46K-SNCA mutation carriers (n = 4), and controls (n = 17). All participants underwent Spectralis retinal optical coherence tomography and Montreal Cognitive Assessment, and Unified Parkinson's Disease Rating Scale score was obtained in patients. Macular ganglion cell-inner plexiform layer complex (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thickness reduction rates were estimated with linear mixed models. Risk ratios were calculated to evaluate the association between baseline GCIPL and pRNFL thicknesses and the risk of subsequent cognitive and motor worsening, using clinically meaningful cutoffs. Results GCIPL thickness in the parafoveal region (1- to 3-mm ring) presented the largest reduction rate. The annualized atrophy rate was 0.63 mu m in iPD patients and 0.23 mu m in controls (p < 0.0001). iPD patients with lower parafoveal GCIPL and pRNFL thickness at baseline presented an increased risk of cognitive decline at 3 years (relative risk [RR] = 3.49, 95% confidence interval [CI] = 1.10-11.1, p = 0.03 and RR = 3.28, 95% CI = 1.03-10.45, p = 0.045, respectively). We did not identify significant associations between retinal thickness and motor deterioration. Interpretation Our results provide evidence of the potential use of optical coherence tomography-measured parafoveal GCIPL thickness to monitor neurodegeneration and to predict the risk of cognitive worsening over time in iPD. ANN NEUROL 2020es_ES
dc.publisherAnnals of Neurologyes_ES
dc.relation.ispartofseries;vol. 89, nº 1
dc.titleRetinal Thickness Predicts the Risk of Cognitive Decline in Parkinson Diseasees_ES
dc.typeArticulo Revista Indexadaes_ES

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