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dc.contributor.authorCalvo, Ana
dc.contributor.authorRoddy, Darren William
dc.contributor.authorCoughlan, Helen
dc.contributor.authorKelleher, Ian
dc.contributor.authorHealy, Colm
dc.contributor.authorHarley, Michelle E.
dc.contributor.authorClarke, Mary
dc.contributor.authorLeemans, Alexander
dc.contributor.authorFrodl, Thomas
dc.contributor.authorO'Hanlon, Erik
dc.contributor.authorCannon, Mary
dc.date2020-06
dc.date.accessioned2020-08-06T11:50:42Z
dc.date.available2020-08-06T11:50:42Z
dc.identifier.citationCalvo A, Roddy DW, Coughlan H, Kelleher I, Healy C, Harley M, et al. (2020) Reduced hippocampal volume in adolescents with psychotic experiences: A longitudinal population-based study. PLoS ONE 15(6): e0233670. https://doi.org/10.1371/journal.pone.0233670es_ES
dc.identifier.issn1932-6203
dc.identifier.urihttps://reunir.unir.net/handle/123456789/10362
dc.description.abstractAims Smaller hippocampal volumes are among the most consistently reported neuroimaging findings in schizophrenia. However, little is known about hippocampal volumes in people who report psychotic experiences. This study investigated differences in hippocampal volume between young people without formal diagnoses who report psychotic experiences (PEs) and those who do not report such experiences. This study also investigated if any differences persisted over two years. Methods A nested case-control study of 25 adolescents (mean age 13.5 years) with reported PEs and 25 matched controls (mean age 13.36 years) without PEs were drawn from a sample of 100 local schoolchildren. High-resolution T1-weighted anatomical imaging and subsequent automated cortical segmentation (Freesurfer 6.0) was undertaken to determine total hippocampal volumes. Comprehensive semi-structured clinical interviews were also performed including information on PEs, mental diagnoses and early life stress (bullying). Participants were invited for a second scan at two years. Results 19 adolescents with PEs and 19 controls completed both scans. Hippocampal volumes were bilaterally lower in the PE group compared to the controls with moderate effects sizes both at baseline [left hippocampus p = 0.024 d = 0.736, right hippocampus p = 0.018, d = 0.738] and at 2 year follow up [left hippocampus p = 0.027 d = 0.702, right = 0.048 d = 0.659] throughout. These differences survived adjustment for co-morbid mental disorders and early life stress. Conclusions Psychotic experiences are associated with total hippocampal volume loss in young people and this volume loss appears to be independent of possible confounders such as co-morbid disorders and early life stress.es_ES
dc.language.isoenges_ES
dc.publisherPLoS ONEes_ES
dc.relation.ispartofseries;vol. 15, nº 6
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233670es_ES
dc.rightsopenAccesses_ES
dc.subjectadolescentes_ES
dc.subjectbrain sizees_ES
dc.subjectbullyinges_ES
dc.subjectcase control studyes_ES
dc.subjectclinical arties_ES
dc.subjectScopuses_ES
dc.subjectJCRes_ES
dc.titleReduced hippocampal volume in adolescents with psychotic experiences: A longitudinal population-based studyes_ES
dc.typeArticulo Revista Indexadaes_ES
reunir.tag~ARIes_ES
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0233670


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