The purpose of this research is to carry out a systematic review of the existing scientific literature on the prevalence of Burnout in university professors in the time period 2005-2020. For that purpose, an exploratory review through the Web of Science (WoS) and Scopus related to this psychosocial syndrome under the PRISMA methodology has been made. After the application of the inclusion and exclusion criteria, a final group of 12 studies were obtained. The results show the presence of high levels of Burnout in a sample of 2,841 university professors in the period studied, which makes it necessary to implement psychosocial intervention programs to prevent this syndrome and promote the personal and professional accomplishment of teachers.