This article focuses on the design and characterization of management model for MSMEs, based on e-commerce and the GS1 international e-com standard. The first part contextualizes electronic commerce and its impact on domestic industry, and briefly describes the B2B e-commerce model used in Colombia. Subsequently the first step to apply the model is presented, which corresponds to the design of a diagnostic methodology that evaluates the technological, technical, commercial and administrative aspects of the organization; after that are exposed the results of the pilot experiment performed on a MSME from Bogota, and finally will be explained the procedures for the implementation of the model.