In these days, we live in a society where technology is everywhere. Some technological devices, such as smartphones, have become almost an extension of ourselves and a fundamental tool to carry out multiple tasks of our daily life. However, in the educational field, it has not been possible to develop the great potential that smartphones have as a teaching resource yet. Its use in the classroom can help us to improve the teaching and learning process, providing new tools to teachers and enhancing the acquisition of certain concepts by students, especially among “Digital Natives”, who are accustomed to using technology. Technological development, new educational applications and studies on the advantages of using the smartphone in the classroom, endorse its use as an educational tool. Therefore, in this work is intended, on the one hand, to investigate the theoretical bases that position the use of Kahoot and EdPuzzle tools through the smartphone and the Master Class, and on the other hand, to design a methodological proposal that includes these tools in an active methodology, in order to achieve a more meaningful and constructivist learning, enhancing the students’ knowledge acquisition.