Efficacy of mebendazole in paediatric patients with giardiasis: A systematic review and meta-analysis
Escobedo, Angel A.
González-Fraile, Eduardo (1)
Tipo de Ítem:Articulo Revista Indexada
Mebendazole (MBZ), a benzimidazole compound, has received attention in treating patients with giardiasis because it has shown beneficial effects both in vitro and in vivo. The aim of this study was to assess with a systematic review and meta-analysis of randomized controlled trials (RCTs) the efficacy of MBZ compared to other antigiardial agents in children. We searched RCTs of MBZ for the treatment of Giardia infections published in PubMed and EBSCOhost. Application of inclusion and exclusion criteria, data extraction, and assessment of methodological quality were independently performed in duplicate. The primary outcome was the parasitological cure. We included 7 RCTs in the systematic review (639 patients). There was no clinical difference in the parasitological cure between MBZ and metronidazole (MTZ). The relative risk (RR) was 0.81 [95% 95% Confidence Interval 0.61–1.09], with high heterogeneity (4 trials, I2 = 81%). The prediction interval expected to cover the results of a new trial was wide enough (0.22–2.96) to support both a clinically relevant difference favouring either MBZ or MTZ. The decision to support any treatment should be based not only on efficacy but also safety and cost. Although our results suggest that MBZ may be an effective treatment option for children with Giardia infection, they should also be interpreted and translated into clinical practice with caution, as the evidence is based on a limited number of RCTs presenting high heterogeneity.
Este ítem aparece en la(s) siguiente(s) colección(es)
Mostrando ítems relacionados por Título, autor o materia.
Mental health professionals’ attitudes towards mental illness: professional and cultural factors in the INTER NOS study Olmo-Romero, Francisco del; González-Blanco, María; Sarró, Salvador; Grácio, Jaime; Martín-Carrasco, Manuel; Martínez-Cabezón, Ana C; Giampaola, Perna; Pomarol-Clotet, Edith; Varandas, Pedro; Ballesteros-Rodríguez, Javier; Rebolleda-Gil, Carlos; Vanni, Giovanna; González-Fraile, Eduardo (1) (European Archives of Psychiatry and Clinical Neuroscience, 2018)BACKGROUND: Research shows that personnel working in mental health facilities may share some of the societal prejudices towards mental illness. This might result in stigmatizing behaviours towards people suffering from ...
Santos-Zorrozua, Borja; González-Fraile, Eduardo (1); Zabala, Arantzazu; Guillén, Virginia; Rueda, Jose R.; Ballesteros, Javier (Journal of Psychopharmacology, 11/2018)Background: Schizophrenia is a severe, persistent mental disorder, and a leading cause of disability worldwide. Cognitive impairments presented in schizophrenia lead to a worse prognostic, thus treatments targeted to enhance ...
Assessment of the consequences of caregiving in psychosis: a psychometric comparison of the Zarit Burden Interview (ZBI) and the Involvement Evaluation Questionnaire (IEQ) Gonçalves-Pereira, Manuel; González-Fraile, Eduardo (1); Santos-Zorrozua, Borja; Martín-Carrasco, Manuel; Fernández-Catalina, Paola; Domínguez-Panchón, Ana I; Muñoz-Hermoso, Paula; Ballesteros, Javier (Health and Quality of Life Outcomes, 04/2017)Background: The Zarit Burden Interview ( ZBI) was originally developed to assess the level of subjective burden in caregivers of people with dementia. The Involvement Evaluation Questionnaire ( IEQ) is amongst the leading ...