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    Dietary choline supplementation in adult rats improves performance on a test of recognition memory

    Autor: 
    Moreno, Hayarelis (1)
    ;
    Hall, Geoffrey
    ;
    Gallo, Milagros
    ;
    Brugada, Isabel de
    Fecha: 
    2018
    Palabra clave: 
    choline; dietary supplementation; memory; object recognition; memory; rat; Scopus; JCR
    Tipo de Ítem: 
    Articulo Revista Indexada
    URI: 
    https://reunir.unir.net/handle/123456789/6663
    DOI: 
    https://doi.org/10.1016/j.bbr.2018.04.030
    Dirección web: 
    https://www.sciencedirect.com/science/article/pii/S0166432817314018?via%3Dihub
    Resumen:
    In two experiments adult rats (aged at least 6 months at the start of the procedure) received a diet enriched with added choline for a period of 10 weeks; control subjects were maintained on a standard diet during this time. All rats then underwent the spontaneous object recognition (SOR) procedure in which they were exposed to a pair of objects and then tested, after a retention interval, to a display with one object changed. Exploration of the changed object indicates retention and use of information acquired during the exposure phase. All subjects showed retention with a 24-h interval (Experiments 1 and 2) and when retested after a further 24 h (Experiment 1). But when tested for the first time after a 48-h interval (Experiment 2), control subjects showed no evidence of retention, exploring both objects equally, whereas those given the dietary supplement continued to show a preference for the changed object. This supports the conclusion that dietary choline supplementation can enhance performance on a task regarded as a test of declarative memory, and will do so even when the supplementations is given in adulthood.
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