Mostrando ítems 1-9 de 9
Multiple recombinant events in human T-cell Leukemia virus Type 1: complete sequences of recombinant African strains
(Emerging Microbes and Infections, 2020-01-01)
Africa is the largest endemic area for HTLV-1, with many molecular genotypes. We previously demonstrated that some strains from North Africa (a-NA clade) originated from a recombinant event between Senegalese and West ...
Antiretroviral Therapy for HIV-2 Infection in Non-Endemic Regions
(AIDS Reviews, 2020-01)
Human immunodeficiency virus type 2 (HIV-2) was isolated in AIDS patients in 1986. Around 1-2 million people are infected worldwide. The virus is less transmissible than HIV-1, being sexual contacts the most frequent route ...
Impact of New Coronavirus Epidemics on HIV-Infected Patients
(AIDS Reviews, 2020)
Since the first report of a cluster of pneumonia cases in Wuhan (China) at the end of 2019 due to a new airborne highly transmissible coronavirus known as SARS-CoV-2, large-scale spreading has rapidly become a global ...
HTLV-1 infection and health outcomes
(The Lancet Infectious Diseases, 2020-04)
The meta-analysis published by Gill Schierhout and colleagues1 reported an increased relative risk of premature death in individuals infected with HTLV-1 compared with individuals not infected with HTLV-1 (RR 1·57, 95% CI ...
Tough requirements for new antiretroviral drugs
(The Lancet HIV, 2020-03)
Medical and social attention to HIV infection has declined globally and is increasingly focused on developing regions, where the epidemic is still largely uncontrolled. In North America and western Europe, AIDS is rarely ...
Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2
(Journal of Infectious Diseases, 2020-06)
Background: HIV-1 and HIV-2 differ in their antiretroviral (ARV) susceptibilities and drug resistance mutations (DRMs). Methods: We analyzed published HIV-2 pol sequences to identify HIV-2 treatment-selected mutations ...
Hospital admissions in individuals with HTLV-1 infection in Spain
OBJECTIVE: To examine the clinical burden and disease spectrum, as well as time trends for human T-cell leukemia virus type 1 (HTLV-1) and HTLV type 2 (HTLV-2) hospital admissions. DESIGN: Retrospective, observational study ...
Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
(International Journal of Infectious Diseases, 2020-08)
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum ...
Long-acting antiretroviral therapy
(Nature Materials, 2020-08-01)
Nanoformulations of cabotegravir prodrugs have been developed to prolong the pharmacokinetics of the antiretroviral agent. They can be present in the plasma of mice and non-human primates for a year following a single injection.